Jump to content

File:Inputs and outputs of KEAP1 NRF2 pathway.jpg

Page contents not supported in other languages.
This is a file from the Wikimedia Commons
From Wikipedia, the free encyclopedia

Original file (2,627 × 2,127 pixels, file size: 514 KB, MIME type: image/jpeg)

Summary

Description
English: Figure 3  The major activating inputs and functional outputs of the NRF2 pathway. NRF2 is activated in response to oxidative stress, metabolic stress, and various oncogenic stress signals upstream. NRF2 is a pleiotropic transcription factor that induces the expression of a plethora of downstream target genes. Highlighted are some of the most well-studied functional outputs of the NRF2 pathway. Glutathione (GSR, GCLC, GCLM, GPX2, and SLC7A11), multidrug resistance–associated proteins (ABCC1 and ABCC2), and thioredoxin (TXN1, PRDX1, TXNRD1, and SRXN1) metabolism proteins mediate detoxification of ROS, drugs, and toxins (see Table 1). The glucose-dependent pentose phosphate pathway enzymes G6PD and PGD and the central carbon metabolism enzymes ME1 and IDH1 increase the reducing capacity of cells by regenerating NADPH. Heme degradation by HMOX1 and iron sequestration by FTL1 and FTH1 maintain heme and iron homeostasis, preventing iron accumulation and ferroptosis.
Date
Source https://www.annualreviews.org/doi/full/10.1146/annurev-cancerbio-030518-055627
Author Warren L. Wu and Thales Papagiannakopoulos

Licensing

w:en:Creative Commons
attribution
This file is licensed under the Creative Commons Attribution 4.0 International license.
You are free:
  • to share – to copy, distribute and transmit the work
  • to remix – to adapt the work
Under the following conditions:
  • attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

Captions

Add a one-line explanation of what this file represents

Items portrayed in this file

depicts

image/jpeg

526,387 byte

2,127 pixel

2,627 pixel

662a953e73dfe1767f4cbd9891c05404195e60ed

File history

Click on a date/time to view the file as it appeared at that time.

Date/TimeThumbnailDimensionsUserComment
current21:21, 12 September 2020Thumbnail for version as of 21:21, 12 September 20202,627 × 2,127 (514 KB)Elysia (AR)Uploaded a work by Warren L. Wu and Thales Papagiannakopoulos from https://www.annualreviews.org/doi/full/10.1146/annurev-cancerbio-030518-055627 with UploadWizard

The following page uses this file:

Metadata