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Summary

Description
English: Replication of the bacteriophage ϕ29 genome.

Per the authors:

"(A) The 3′-terminal region of bacteriophage ϕ29 genome. (B) The p6 protein (red) destabilizes the ends of the DNA, making replication possible. The initiation of replication of bacteriophage ϕ29 occurs through the terminal protein p3 (green) which is covalently bound to the 5′ end. DNA polymerase (orange) in complex with p3 protein and dAMP pairs the first nucleotide with the penultimate T from the template. A sliding-back mechanism then occurs, which results in the entire complex moving to the +1 position of the newly synthesized strand, allowing re-matching at the penultimate template site. The ssDNA is covered by p5 SSB (blue). Schemes follow the same formatting."
Date
Source https://www.mdpi.com/1422-0067/23/2/635/htm
Author Joanna Morcinek-Orłowska, Karolina Zdrojewska, and Alicja Węgrzyn

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Captions

The DNA replication mechanism of bacteriophage Φ29.

7 January 2022

image/webp

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Date/TimeThumbnailDimensionsUserComment
current23:03, 2 November 2022Thumbnail for version as of 23:03, 2 November 20222,163 × 2,026 (450 KB)TheNthEditorHigher resolution (from same article)
22:57, 2 November 2022Thumbnail for version as of 22:57, 2 November 2022550 × 515 (21 KB)TheNthEditorUploaded a work by Joanna Morcinek-Orłowska, Karolina Zdrojewska, and Alicja Węgrzyn from https://www.mdpi.com/1422-0067/23/2/635/htm with UploadWizard

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