DescriptionHis296, Asp345, and Ser441 catalytic triad.png
English: shows the His296, Asp345, and
Ser441 catalytic triad within the Serine Peptidase
domain on TMPRSS2 that is characteristic of almost
all Type II Serine proteases. The serine (green)
engages in nucleophilic attack, the histidine (cyan)
acts as a general base to reset the serine and the
aspartate (magenta) neutralizes the histidine in
transition states during reactions that cause
proteolytic cleavage. This structure was solved via x-ray crystallography with a resolution of 1.95 Angstroms (PDB: 7MEQ) (1). Image made in Chimera.
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