File:HIF Nobel Prize Physiology Medicine 2019 Hegasy ENG.png
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Summary
| Description |
English: Nobel Prize in Physiology or Medicine 2019: How Cells Sense and Adapt to Oxygen Availability.
Under normoxic conditions, Hif-1 alpha is hydroxylated at two proline residues. The protein then associates with VHL and is subsequently tagged with ubiquitin. Tagged Hif-1 alpha is then translocated to the proteasome, where it is degraded. Under hypoxic conditions, no oxygen is available for proline hydroxylation. In this situation Hif-1 alpha translocates to the cell nucleus and associates with Hif-1 beta, also termed ARNT. This complex then binds to a DNA region termed HRE (hypoxia responsive element). As a consequence target genes are transcribed. These genes are involved in the regulation of a multitude of processes, including erythropoesis, glycolysis and angiogenesis. |
| Date | |
| Source | Own work |
| Author | Dr. Guido Hegasy |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 12:07, 9 October 2019 | | 3,508 × 2,480 (1.26 MB) | Guido4 | Typo corrected, changed some colors |
| 16:06, 8 October 2019 |  | 3,508 × 2,480 (1.26 MB) | Guido4 | User created page with UploadWizard |
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