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Description A model of transport mechanisms in the distal convoluted tubule. Sodium-chloride (NaCl) enters the cell via the apical thiazide-sensitive NCC and leaves the cell through the basolateral Cl- channel (ClC-Kb), and the Na+/K+-ATPase. Indicated also are the recently identified magnesium channel TRPM6 in the apical membrane, and a putative Na/Mg exchanger in the basolateral membrane. These transport mechanisms play a role in familial hypokalemia-hypomagnesemia or Gitelman's syndrome.
Date Published: 30 July 2008
Source Orphanet Journal of Rare Diseases 2008, 3:22. doi:10.1186/1750-1172-3-22
Author Nine VAM Knoers and Elena N Levtchenko

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current19:52, 21 December 2008Thumbnail for version as of 19:52, 21 December 2008656 × 650 (74 KB)Stevenfruitsmaak{{Information |Description=A model of transport mechanisms in the distal convoluted tubule. Sodium-chloride (NaCl) enters the cell via the apical thiazide-sensitive NCC and leaves the cell through the basolateral Cl- channel (ClC-Kb), and the Na+/K+-ATPas

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