File:Fmolb-07-585899-g001.jpg
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Sefhgs
Summary
| Description |
English: Graphic showing seven possible drug targets in viral replication process and drugs. Target 1: Spike protein blocked by arbidol and monoclonal antibodies which could bind with ACE2. Target 2: ACE2 intervened by azithromycin and chloroquine to inhibit formation of ACE2 and S protein complex. Target 3: TMPRSS2 inhibited by Camostat Mesylate to block cleavage and S protein activation. Target 4: Proteases inhibited by ritonavir, lopinavir, and/or oseltamivir that inhibit viral replication. Target 5: Endosomes targeted by chloroquine and its derivatives to increase pH and block viral RNA release from endosomes. Target 6: RdRp intervened by remdisivir, favipiravir, and/or ribavirin and cause premature termination of RNA synthesis. |
| Date | |
| Source |
Sumon TA, Hussain MA, Hasan MT, Hasan M, Jang WJ, Bhuiya EH, Chowdhury AAM, Sharifuzzaman SM, Brown CL, Kwon H-J and Lee E-W (2021) A Revisit to the Research Updates of Drugs, Vaccines, and Bioinformatics Approaches in Combating COVID-19 Pandemic. Front. Mol. Biosci. 7:585899. https://doi.org/10.3389/fmolb.2020.585899 |
| Author | Tofael Ahmed Sumon, Md. Ashraf Hussain, Md. Tawheed Hasan, Mahmudul Hasan4, Won Je Jang, Eleus Hussain Bhuiya, Abdullah Al Mamun Chowdhury, S. M. Sharifuzzaman, Christopher Lyon Brown, Hyun-Ju Kwon, and Eun-Woo Lee |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 11:05, 2 February 2021 | | 1,084 × 929 (521 KB) | Guest2625 | Uploaded a work by Tofael Ahmed Sumon, Md. Ashraf Hussain, Md. Tawheed Hasan, Mahmudul Hasan4, Won Je Jang, Eleus Hussain Bhuiya, Abdullah Al Mamun Chowdhury, S. M. Sharifuzzaman, Christopher Lyon Brown, Hyun-Ju Kwon, and Eun-Woo Lee from Sumon TA, Hussain MA, Hasan MT, Hasan M, Jang WJ, Bhuiya EH, Chowdhury AAM, Sharifuzzaman SM, Brown CL, Kwon H-J and Lee E-W (2021) A Revisit to the Research Updates of Drugs, Vaccines, and Bioinformatics Approaches in Combating COVID-19 Pandemic. Front. Mol... |
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