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English: Crosstalk between immune system and CNS system cytokine networks. There is a supposed link between the immune system cytokine network and the CNS system cytokine network. Peripheral cytokines can cross the blood brain barrier to enter the CNS. Alternatively, microglia and astrocytes can also produce cytokines. Potential involvement of neurons in regulation of cytokines for example brain-derived neurotrophic factor (BDNF) and interleukin-6 levels is also plausible. SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; COVID-19, coronavirus disease 2019; CNS, central nervous system; IL, interleukin; TNF, tumor necrosis factor; IFN, interferon.
Date
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Bhaskar S, Sinha A, Banach M, Mittoo S, Weissert R, Kass JS, Rajagopal S, Pai AR and Kutty S (2020) Cytokine Storm in COVID-19—Immunopathological Mechanisms, Clinical Considerations, and Therapeutic Approaches: The REPROGRAM Consortium Position Paper. Front. Immunol. 11:1648.

https://doi.org/10.3389/fimmu.2020.01648
Author Sonu Bhaskar, Akansha Sinha, Maciej Banach, Shikha Mittoo, Robert Weissert, Joseph S. Kass, Santhosh Rajagopal, Anupama R. Pai, and Shelby Kutty

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Crosstalk between immune system and CNS system cytokine networks.

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10 July 2020

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Date/TimeThumbnailDimensionsUserComment
current11:15, 3 February 2021Thumbnail for version as of 11:15, 3 February 2021957 × 869 (324 KB)Guest2625Uploaded a work by Sonu Bhaskar, Akansha Sinha, Maciej Banach, Shikha Mittoo, Robert Weissert, Joseph S. Kass, Santhosh Rajagopal, Anupama R. Pai, and Shelby Kutty from Bhaskar S, Sinha A, Banach M, Mittoo S, Weissert R, Kass JS, Rajagopal S, Pai AR and Kutty S (2020) Cytokine Storm in COVID-19—Immunopathological Mechanisms, Clinical Considerations, and Therapeutic Approaches: The REPROGRAM Consortium Position Paper. Front. Immunol. 11:1648. https://doi.org/10.3389/fimmu.2020.01648 with Upl...

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