File:Extrinsic and intrinsic pathways to caspase-3 activation.jpg
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| Description |
Čeština: Vnitřní a vnější cesty aktivace kaspázy 3: DISC (death-inducing signaling complex), MAC (mitochondrial apoptosis-induced channel) a apoptosom
English: Figure 1. Extrinsic and intrinsic pathways to caspase-3 activation. Overview of pathways to caspase-3 activation. Each separate gray region represent the three modules: DISC (death-inducing signaling complex), MAC (mitochondrial apoptosis-induced channel) and apoptosome. Species and their symbols are: FasL (FasL), FasR (FasR), DISC (DISC), procaspase-8 and caspase-8 (Casp8), bifunctional apoptosis inhibitor (BAR), procaspase-3 and caspase-3 (Casp3), XIAP (XIAP), Bid and truncated Bid (Bid), Bax (Bax), tBid - Bax2 complex (tBid - Bax2), Smac (Smac), Apaf-1 (Apaf), cytochrome c (Cytc), apoptosome (Apop), procaspase-9 and caspase-9 (Casp9). Arrows denote chemical conversions or catalyzed reactions while hammerheads represent inhibition. |
| Date | |
| Source | Construction and analysis of a modular model of caspase activation in apoptosis |
| Author | Harrington HA, Ho KL, Ghosh S, Tung KC |
| Permission (Reusing this file) |
© 2008 Harrington et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.  This file is licensed under the Creative Commons Attribution 2.5 Generic license.
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 10:30, 13 September 2009 | | 1,200 × 984 (89 KB) | CopperKettle | {{Information |Description={{en|1=Figure 1. Extrinsic and intrinsic pathways to caspase-3 activation. Overview of pathways to caspase-3 activation. Each separate gray region represent the three modules: DISC (death-inducing signaling complex), MAC (mitoch |
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