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English: The helix-loop-helix EF-hand Ca2+ binding motif. (A), Cartoon illustration of the canonical EF-hand Ca2+-binding motif. The EF-hand motif contains a 29-residue helix-loop-helix topology, much like the spread thumb and forefinger of the human hand. Ca2+ is coordinated by ligands within the 12-residue loop, including seven oxygen atoms from the sidechain carboxyl or hydroxyl groups (loop sequence positions 1, 3, 5, 12), a main chain carbonyl group (position 7), and a bridged water (via position 9). Residue at position 12 serves as a bidentate ligand. The Ca2+ binding pocket adopts a pentagonal bipyramidal geometry. n stands for hydrophobic residue. (B), HMM logo for the canonical EF hand motif (http://pfam.sanger.ac.uk/family?acc=PF00036). The conservation of amino acids at several positions makes it possible to predict EF-hand motifs from genomic sequences. (C), 3D structure of a typical canonical EF-hand motif from calmodulin (PDB code: 3cln). Ca2+ is chelated by ligands from a 12-residue loop. (D), 3D structure of an EF-hand-like motif from a soluble fragment of lytic transglycosylase B of Escherichia coli (PDB code: 1qut). This motif contains a 15-residue (instead of 12-residue) Ca2+-binding loop flanked by two helices.
Date
Source Cell Calcium. 2009 Jul;46(1):1-17.
Author Zhou Yubin, Frey K Frey, Yang J Jenny.

Reference: Viral calciomics: interplays between Ca2+ and virus. Zhou Y, Frey TK, Yang JJ. Cell Calcium. 2009 Jul;46(1):1-17. Review. PMID: 19535138

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31 August 2009

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current18:52, 28 August 2009Thumbnail for version as of 18:52, 28 August 20091,440 × 1,081 (343 KB)Zooyoyo811001{{Information |Description={{en|1=The helix-loop-helix EF-hand Ca<sup>2+</sup> binding motif. (A), Cartoon illustration of the canonical EF-hand Ca<sup>2+</sup>-binding motif. The EF-hand motif contains a 29-residue helix-loop-helix topology, much like th

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