DescriptionDrug discovery research workflow - journal.pbio.1001379.g001.png
English: Overview of the evolutionary method used to discover a novel vascular disrupting agent.
Strict reliance on the evolutionary conservation of the relevant gene module allowed for an experimental design exploiting the unique experimental advantages of each model organism, thus speeding the search for novel angiogenesis inhibitors. (Vector female silhouette under Creative Commons Attribution 2.0 from ‘Keep Fit’ Vector Pack, Blog.SpoonGraphics.)
Date
Source
Cha HJ, Byrom M, Mead PE, Ellington AD, Wallingford JB, et al. (2012) Evolutionarily Repurposed Networks Reveal the Well-Known Antifungal Drug Thiabendazole to Be a Novel Vascular Disrupting Agent. PLoS Biol 10(8): e1001379. doi:10.1371/journal.pbio.1001379
Author
Cha HJ, Byrom M, Mead PE, Ellington AD, Wallingford JB, et al. (2012)
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