File:Complement pathway.svg

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Summary

Description

English: The complement system is made up of about 25 proteins that work together to “complement” the action of antibodies in destroying bacteria. Complement proteins circulate in the blood in an inactive form. When the first protein in the complement series is activated— typically by antibody that has locked onto an antigen—it sets in motion a domino effect. Each component takes its turn in a precise chain of steps known as the complement cascade. The end product is a cylinder inserted into—and puncturing a hole in—the cell’s wall. With fluids and molecules flowing in and out, the cell swells and bursts.

Deutsch: Das Komplementsystem besteht aus etwa 25 Proteinen, die zusammen die Immunantwort von Antikörpern ergänzen (komplementieren) um so Bakterien zu zerstören. Komplement-Proteine zirkulieren in einer inaktiven Form im Blut. Wenn das erste Protein der Komplement-Kaskade aktiviert wird - typischerweise durch einen Antikörper, der an ein Antigen gebunden hat, kommt es zu einem Domino-Effekt. Jede Komponente aktiviert die nachfolgende in einer Kette von Schritten, die als Komplement-Kaskade bezeichnet wird. Das Endprodukt ist ein Zylinder in der Membran der Zielzelle, der ein Loch in die Zellmembran stanzt. Dies führt zum Austausch von Molekülen und Flüssigkeit zwischen Zellinnerem und Umgebung, die Zelle schwillt an und platzt.

Nederlands: Complementsysteem

Čeština: Komplement sestává z neaktivních proteinů, které se aktivují kaskádovitě třemi známými cestami - alternativní, klasickou a lektinovou. Doplňuje imunitní protilátkovou odpověď proti bakteriím.

Français : Le Système du complément est composé d'environ 25 protéines travaillant ensemble pour "compléter" l'action anti-bactérienne des anticorps. Ces protéines circulent dans le sang sous forme inactive. Lorsque la première de la série est activée, typiquement par un anticorps ayant capté un antigène, les autres s'activent par effet domino : chaque complément prend effet tour à tour en cascade. Le résultat final est un cylindre transperçant la paroi de la cellule. Les fluides et molécules circulent alors librement entre l'intérieur et l'extérieur, faisant gonfler la cellule jusqu'à son explosion.

Date NIH Publication No. 03–5423, September 2003 (modifications: September 4, 2006) (SVG 1 December 2015)

Source Own work based on: http://www.niaid.nih.gov/publications/immune/the_immune_system.pdf

Author

English text of 'Image:Complement pathway.png' by DO11.10
German translation of 'Image:Complement pathway.png' by Hduman
Galician translation Miguelferig
Catalan translation Leptictidium
Spanish translation Asierog
SVG by Perhelion

Permission
(Reusing this file) Original work of the US Federal Government - public domain

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File history

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	Date/Time	Dimensions	User	Comment
current	00:53, 29 September 2020	1,680 × 2,024 (26 KB)	Asierog	Spanish translation added, C2a changed for C2b in all languages
	12:16, 6 February 2020	1,680 × 2,024 (24 KB)	Whidou	Add French translation
	14:29, 16 June 2019	1,680 × 2,024 (23 KB)	SMP	Catalan spelling
	01:33, 6 September 2016	1,680 × 2,024 (23 KB)	DadOfBeanAndBug	Reverted to version as of 01:30, 6 September 2016 (UTC)
	01:31, 6 September 2016	1,680 × 2,024 (23 KB)	DadOfBeanAndBug	Reverted to version as of 20:44, 1 December 2015 (UTC)
	01:30, 6 September 2016	1,680 × 2,024 (23 KB)	DadOfBeanAndBug	en: changed membran -> membrane
	20:44, 1 December 2015	1,680 × 2,024 (23 KB)	Perhelion	lang +ca +gl (+fix de)
	12:38, 1 December 2015	1,680 × 2,020 (20 KB)	Perhelion	minor tweak
	01:40, 1 December 2015	1,680 × 2,020 (27 KB)	Perhelion	=={{int:filedesc}}== {{Information \|Description= {{en\|The complement system is made up of about 25 proteins that work together to “complement” the action of antibodies in destroying bacteria. Complement proteins circulate in the blood in an inactiv...