Jump to content

File:Classic leptin–melanocortin model.jpg

Page contents not supported in other languages.
This is a file from the Wikimedia Commons
From Wikipedia, the free encyclopedia

Original file (2,128 × 3,029 pixels, file size: 388 KB, MIME type: image/jpeg)

Summary

Description
English: " Leptin is secreted predominantly by the adipose tissue and reaches the brain parenchyma through the bloodstream. The arcuate nucleus of the hypothalamus (ARC) hosts AGRP/NPY and POMC neurons, two distinct antagonistic neuronal populations that have been shown to express Lepr-b (Cheung et al., 1997; Mercer, Hoggard, Williams, Lawrence, Hannah, Morgan, et al., 1996; Mercer, Hoggard, Williams, Lawrence, Hannah, & Trayhurn, 1996). This model proposed that leptin acts directly on those neurons to induce opposite effects. Thus, high leptin levels, signaling a positive energy state, would activate POMC neurons and inhibit AGRP/NPY neurons to promote satiety. On the other hand, low leptin levels would activate AGRP/NPY neurons and inhibit POMC neurons, promoting food intake. Once activated, the first-order AGRP/NPY and POMC neurons would affect second-order neurons, located outside of the ARC, by releasing NPY, AGRP, or POMC-derived α-MSH. Via their action on second-order neurons, these peptides would then induce broad effects on energy homeostasis (Schwartz et al., 2000). AGRP, agouti-related peptide; LEPR, leptin receptor; NPY, neuropeptide Y; POMC, pro-opiomelanocortin; α-MSH, α-melanocyte-stimulating hormone."
Date 17 January 2023
Source https://onlinelibrary.wiley.com/doi/10.1111/jnc.15765
Author Olivier Lavoie, Natalie Jane Michael, Alexandre Caron

Licensing

w:en:Creative Commons
attribution share alike
This file is licensed under the Creative Commons Attribution-Share Alike 4.0 International license.
You are free:
  • to share – to copy, distribute and transmit the work
  • to remix – to adapt the work
Under the following conditions:
  • attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • share alike – If you remix, transform, or build upon the material, you must distribute your contributions under the same or compatible license as the original.

Captions

Add a one-line explanation of what this file represents

Items portrayed in this file

depicts

image/jpeg

97931c53a7745c33f4de3084f96f6773f3ba312a

396,933 byte

3,029 pixel

2,128 pixel

File history

Click on a date/time to view the file as it appeared at that time.

Date/TimeThumbnailDimensionsUserComment
current01:25, 6 December 2023Thumbnail for version as of 01:25, 6 December 20232,128 × 3,029 (388 KB)BuidheUploaded a work by Olivier Lavoie, Natalie Jane Michael, Alexandre Caron from https://onlinelibrary.wiley.com/doi/10.1111/jnc.15765 with UploadWizard

The following page uses this file: