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Deutsch: DNA des menschlichen Chromosoms 2 wurde markiert, per Fluoreszenz in situ Hybridisierung auf Metaphase-Chromosomen des Orang-Utan (links) und des Menschen (rechts) gegeben und grün angefärbt. Während beim Menschen dadurch nur die beiden Kopien des Chromosoms 2 angefärbt wurden, wurden beim Orang-Utan die Kopien der beiden ursprünglichen Chromosomen markiert (siehe de:Chromosom #Chromosomenevolution ). Die restlichen Chromosomen sind durch eine DNA-Färbung rot gefärbt. Das menschliche Chromosom 2 setzt sich aus Teilen zusammen, die bei den Menschenaffen noch auf zwei Chromosomen verteilt sind. Die Fusion fand also nach der Trennung von den Schimpansen statt. Der Fusionspunkt liegt bei 2q13-14.
English: DNA of the human chromosome 2 was labeled, applied to Orang-Utan (left) and human metaphase chromosomes (right) by fluorescence in situ hybridization and detected in green. While in the human metaphase spread only the two copies of chromosome 2 were detected, in the Orang-Utan metaphase spread the two original chromosome pairs were painted: Human chromosome 2 is the evolutionary derived fusion product from two separate ancestral chromosomes. In non-human primates - like for example in the Orang-Utan (chromosomes on the left side) - as well as in several other mammals, two chromosomes are observed which carry human chromosome 2 orthologous genes and syntenic segments of orthologous DNA sequences. The fusion in human 2q13-14 at approximately 114 Mbp of the human reference sequence (see Ensembl) occurred after the split of the human and chimpanzee lineages from that of their last common ancestor.
Date
Source Stefan Müller, Department Biologie II der Ludwig-Maximilians-Universität München.
Author Verena Schubel, Stefan Müller, Department Biologie der Ludwig-Maximilians-Universität München.
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current21:51, 19 December 2006Thumbnail for version as of 21:51, 19 December 2006484 × 275 (42 KB)Dietzel65{{Information |Description= '''Deutsch''': DNA des menschlichen Chromosoms 2 wurde markiert, per Fluoreszenz in situ Hybridisierung auf Metaphase-Chromosomen des Orang-Utan (links) und des Menschen (rechts) gegeben und gelb angefärbt. Während beim Mensc

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