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File:Atypical ductal hyperplasia with immunotyping.jpg

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Summary

Description
English: Histological appearance of atypical ductal hyperplasia (ADH) and immunohistochemical phenotype.
- A - One focus (< 2 mm) of two architecturally disarranged cross sections of tubuli showing a monotonous intraductal proliferation with secondary intraluminal architecture. Hematoxylin and Eosin stain.
- B - One area of an ADH with associated calcifications intraluminal. Hematoxylin and Eosin stain.
- C - Higher magnification of ADH shows low-grade nuclear atypia and monotonous cell proliferation along with secondary intraluminal architecture. Hematoxylin and Eosin stain.
- D - Strong and uniform expression of estrogen receptors (ER). ER immunohistochemistry.
- E - Lack of basal cytokeratins (CK5/6). CK5/6 immunohistochemistry
Date
Source

(2018). "Atypical ductal hyperplasia and the risk of underestimation: tissue sampling method, multifocality, and associated calcification significantly influence the diagnostic upgrade rate based on subsequent surgical specimens". Breast Cancer 26 (4): 452–458. DOI:10.1007/s12282-018-00943-2. ISSN 1340-6868.

Author Christoph J. Rageth, Ravit Rubenov, Cristian Bronz, Daniel Dietrich, Christoph Tausch, Ann-Katrin Rodewald, Zsuzsanna Varga
Other versions
Crop of A and C.

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Captions

Atypical ductal hyperplasia with immunotyping

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27 December 2018

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current11:24, 2 October 2019Thumbnail for version as of 11:24, 2 October 20191,772 × 1,085 (783 KB)Mikael HäggströmUser created page with UploadWizard

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