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File:Anti-VEGF 165 and anti-IFNy aptamer secondary structure prediction.jpg

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Anti-VEGF_165_and_anti-IFNy_aptamer_secondary_structure_prediction.jpg (520 × 417 pixels, file size: 24 KB, MIME type: image/jpeg)

Summary

Description
English: Illustration of the complex secondary structure of anti-VEGF_165 and anti-IFNy DNA aptamers engineered post-SELEX to improve their properties. These contain two unnatural bases (in yellow) and thymidine-conjugated biotin. Hairpin regions (red) enhance thermal stability. This is an open access article distributed under the terms of the Creative Commons CC BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You are not required to obtain permission to reuse this article.
Date
Source Kimoto, M., Shermane Lim, Y. W., & Hirao, I. (2019). Molecular affinity rulers: systematic evaluation of DNA aptamers for their applicabilities in ELISA. Nucleic acids research, 47(16), 8362-8374. Publisher: Oxford University Press.
Author Michiko Kimoto, Yun Wei Shermane Lim, Ichiro Hirao

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Captions

Secondary structure prediction of DNA aptamers, showing post-SELEX optimizations.

8 August 2019

image/jpeg

ffb87169772c1672cc8a46751c74915ca53201d4

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417 pixel

520 pixel

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