File:Amlodipine and major metabolite.svg
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Original file (SVG file, nominally 302 × 106 pixels, file size: 15 KB)
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Summary
| Description |
English: Amlodipine and one of its major metabolites. The amine group is oxidated and the side ester chains are hydrolyzed.
Español: Amlodipino y uno de sus metabolitos principales. El se oxida el grupo amino y se hidrolizan los grupos de éster. |
| Date | |
| Source | Own work |
| Author | Persia Salehi |
References:
- Zhu, Yanlin; Wang, Fen; Li, Quan; Zhu, Mingshe; Du, Alicia; Tang, Wei; Chen, Weighing (2014). "Amlodipine Metabolism in Human Liver Microsomes and Roles of CYP3A4/5 in the Dihydropyridine Dehydrogenation". Drug Metabolism and Disposition 42 (2): 245-249. DOI:10.1124/dmd.113.055400. PMID 24301608. ISSN 0090-9556.
Made using the chemfig package in LaTex.
\documentclass[10pt]{article}
\usepackage{chemfig}
\setdoublesep{0.091 cm} % Bond Spacing
\setatomsep{14.4 pt} % Bond length
\setcrambond{2 pt}{1 pt}{2.5 pt} % {Bold width}{1pt}{Hash spacing}
\setbondoffset{1.6 pt} % Margin Width
\setbondstyle{line width=0.6 pt} % Line width
\renewcommand*\printatom[1]{\normalsize \ensuremath{\mathsf{#1}}}
\begin{document}
\schemestart
\chemfig{
-[:90]O -[:30] (=[:90,0.75]O) -[:-30]
*6(
= (-[:210])
-\chembelow{N}{H}
- (-[:-30] -[:30]O -[:-30] -[:30] -[:-30]NH_2 )
= ( -[:30](=[:90,0.75]O) -[:-30]O -[:30] )
- ( -[:90,1.5] *6( - (-[,.75]Cl)
=
-
=
-
=
) )
- )
}
\arrow{->}
\hspace{0.7 cm}
\chemfig{
-[:90]O -[:30] (=[:90,0.75]O) -[:-30]
*6(
=[,,,,magenta] (-[:210])
-[,,,,magenta]\color{magenta}{N}
=[,,,,magenta] (-[:-30] -[:30]\color{magenta}{OH} )
-[,,,,magenta] ( -[:30](=[:90,0.75]O) -[:-30]\color{magenta}{OH} )
=[,,,,magenta] ( -[:90,1.5] *6( - (-[,.75]Cl)
=
-
=
-
=
) )
-[,,,,magenta] )
}
\schemestop
\end{document}
Licensing
|
This image of a simple structural formula is ineligible for copyright and therefore in the public domain, because it consists entirely of information that is common property and contains no original authorship. |  |
File history
Click on a date/time to view the file as it appeared at that time.
| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 04:32, 12 July 2017 | | 302 × 106 (15 KB) | Prof. Squirrel | Changed to comply with Wikipedia style guide for chemicals |
| 17:01, 4 July 2017 |  | 362 × 130 (17 KB) | Prof. Squirrel | User created page with UploadWizard |
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