File:Activation mechanisms of CAR.png
Size of this preview: 800 × 505 pixels. Other resolutions: 320 × 202 pixels | 640 × 404 pixels | 1,024 × 646 pixels | 1,280 × 808 pixels | 2,560 × 1,615 pixels | 7,271 × 4,588 pixels.
Original file (7,271 × 4,588 pixels, file size: 739 KB, MIME type: image/png)
 | This is a file from the Wikimedia Commons. Information from its description page there is shown below. Commons is a freely licensed media file repository. You can help. |
Summary
| Description |
English: Inactivated CAR is retained in the cytosol. Upon binding of TCPOBOP, CAR gets dephosphorylated by PP2A and translocates into the nucleus. Here, it forms a complex with RXR and binds to the PB-responsive enhancer module. Another possibility to activate CAR is the indirect activation through PB. PB binds competitively to EGFR, thus inducing the dephosphorylation of RACK-1. RACK-1 then stimulates PP2A to dephosphorylate CAR, which is then translocated into the nucleus. |
| Date | |
| Source | Own work |
| Author | LisaMausi123 |
Licensing
I, the copyright holder of this work, hereby publish it under the following license:
This file is licensed under the Creative Commons Attribution-Share Alike 4.0 International license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- share alike – If you remix, transform, or build upon the material, you must distribute your contributions under the same or compatible license as the original.
File history
Click on a date/time to view the file as it appeared at that time.
| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 14:14, 19 December 2014 | | 7,271 × 4,588 (739 KB) | LisaMausi123 | User created page with UploadWizard |
File usage
The following page uses this file:
