File:ATM target proteins (new).png

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Summary

DescriptionATM target proteins (new).png	English: ATM-mediated two-step response to DNA double strand breaks. In the rapid response activated ATM phosphorylates effector kinase CHK2 which phosphorylates CDC25A, targeting it for ubiquitination and degradation. Therefore phosphorylated CDK2-Cyclin accumulates and progression through the cell cycle is blocked. In the delayed response ATM phosphorylates the inhibitor of p53, MDM2, and p53 which is also phosphorylated by Chk2. The resulting activation and stabilization of p53 leads to an increased expression of Cdk inhibitor p21, which further helps to keep Cdk activity low and to maintain long-term cell cycle arrest.
Date	21 June 2010, 19:11 (UTC)
Source	Own work (Original text: I (Cellular Biochemistry II (talk)) created this work entirely by myself.)
Author	Cellular Biochemistry II (talk)

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Date/Time	Dimensions	User	Comment
2010-06-21 20:54	2961×2346× (93304 bytes)	Cellular Biochemistry II	{{Information \|Description = \|Source = I (~~~) created this work entirely by myself. \|Date = ~~~~~ \|Author = ~~~ \|other_versions = }}
2010-06-21 19:15	2955×2339× (92620 bytes)	Cellular Biochemistry II	{{Information \|Description = \|Source = I (~~~) created this work entirely by myself. \|Date = ~~~~~ \|Author = ~~~ \|other_versions = }}
2010-06-21 19:14	3940×3118× (135063 bytes)	Cellular Biochemistry II	{{Information \|Description = \|Source = I (~~~) created this work entirely by myself. \|Date = ~~~~~ \|Author = ~~~ \|other_versions = }}
2010-06-21 19:14	4925×3897× (181778 bytes)	Cellular Biochemistry II	{{Information \|Description = \|Source = I (~~~) created this work entirely by myself. \|Date = ~~~~~ \|Author = ~~~ \|other_versions = }}
2010-06-21 19:13	9850×7794× (75632 bytes)	Cellular Biochemistry II	{{Information \|Description = \|Source = I (~~~) created this work entirely by myself. \|Date = ~~~~~ \|Author = ~~~ \|other_versions = }}
2010-06-21 19:11	11857×9386× (109231 bytes)	Cellular Biochemistry II	{{Information \|Description = \|Source = I (~~~) created this work entirely by myself. \|Date = ~~~~~ \|Author = ~~~ \|other_versions = }}

File history

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	Date/Time	Dimensions	User	Comment
current	20:04, 1 October 2016	2,961 × 2,346 (43 KB)	Cmdrjameson	Compressed with pngout. Reduced by 48kB (53% decrease).
	04:53, 26 August 2015	2,961 × 2,346 (91 KB)	OgreBot	(BOT): Reverting to most recent version before archival
	04:53, 26 August 2015	2,955 × 2,339 (90 KB)	OgreBot	(BOT): Uploading old version of file from en.wikipedia; originally uploaded on 2010-06-21 19:15:59 by Cellular Biochemistry II
	04:53, 26 August 2015	3,940 × 3,118 (132 KB)	OgreBot	(BOT): Uploading old version of file from en.wikipedia; originally uploaded on 2010-06-21 19:14:59 by Cellular Biochemistry II
	04:53, 26 August 2015	4,925 × 3,897 (178 KB)	OgreBot	(BOT): Uploading old version of file from en.wikipedia; originally uploaded on 2010-06-21 19:14:13 by Cellular Biochemistry II
	04:53, 26 August 2015	9,850 × 7,794 (74 KB)	OgreBot	(BOT): Uploading old version of file from en.wikipedia; originally uploaded on 2010-06-21 19:13:12 by Cellular Biochemistry II
	04:53, 26 August 2015	11,857 × 9,386 (107 KB)	OgreBot	(BOT): Uploading old version of file from en.wikipedia; originally uploaded on 2010-06-21 19:11:50 by Cellular Biochemistry II
	04:50, 26 August 2015	2,961 × 2,346 (91 KB)	NickW557	Transferred from en.wikipedia