English: In enzymology, a 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) is an enzyme that catalyzes the chemical reaction ATP + 5-formyltetrahydrofolate (folinic acid) {\displaystyle \rightleftharpoons }\rightleftharpoons ADP + phosphate + 5,10-methenyltetrahydrofolate
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