Jump to content

File:3puf rnaseH2 AGS mutations.png

Page contents not supported in other languages.
This is a file from the Wikimedia Commons
From Wikipedia, the free encyclopedia

Original file (800 × 1,200 pixels, file size: 422 KB, MIME type: image/png)

Summary

Description
English: The human ribonuclease H2 complex. The catalytic subunit (RNASEH2A) is in light blue, the structural subunit RNASEH2B is in brown, and the structural subunit RNASEH2C is in pink. The position of the catalytic residues in the A subunit is indicated with magenta spheres. The positions of residues whose mutation is associated with Aicardi-Goutieres Syndrome are indicated in yellow, with the exception of the most common AGS mutation (A177T in the B subunit), which is shown with a green sphere.

Rendered from PDB 3PUF chains A, B, C, described in the paper:

The structural and biochemical characterization of human RNase H2 complex reveals the molecular basis for substrate recognition and Aicardi-Goutieres syndrome defects.

Figiel, M., Chon, H., Cerritelli, S.M., Cybulska, M., Crouch, R.J., Nowotny, M.

(2011) J.Biol.Chem. 286: 10540-10550

PubMed: 21177858 PubMedCentral: PMC3060507

DOI: 10.1074/jbc.M110.181974
Date
Source Own work
Author Opabinia regalis

Licensing

I, the copyright holder of this work, hereby publish it under the following licenses:
w:en:Creative Commons
attribution share alike
This file is licensed under the Creative Commons Attribution-Share Alike 4.0 International license.
You are free:
  • to share – to copy, distribute and transmit the work
  • to remix – to adapt the work
Under the following conditions:
  • attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • share alike – If you remix, transform, or build upon the material, you must distribute your contributions under the same or compatible license as the original.
GNU head Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.2 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the section entitled GNU Free Documentation License.
You may select the license of your choice.

Captions

Add a one-line explanation of what this file represents

Items portrayed in this file

depicts

2 March 2017

image/png

d08b11a6d247557393bd0c6a7325379b010b15db

432,190 byte

1,200 pixel

800 pixel

File history

Click on a date/time to view the file as it appeared at that time.

Date/TimeThumbnailDimensionsUserComment
current03:06, 3 March 2017Thumbnail for version as of 03:06, 3 March 2017800 × 1,200 (422 KB)Opabinia regalis{{Information |Description ={{en|1=The human ribonuclease H2 complex. The catalytic subunit (RNASEH2A) is in light blue, the structural subunit RNASEH2B is in brown, and the structural subunit RNASEH2C is in pink. The position of the catalytic resid...

The following 2 pages use this file:

Global file usage

The following other wikis use this file:

Metadata