File:2h1l LTag p53.png
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Summary
| Description |
English: The hexameric assembly of the SV40 polyomavirus large tumor antigen (LTag) zinc finger and helicase domains (rainbow) bound to the human tumor suppressor p53 (light blue). This interaction is one of several protein-protein interactions between the virally encoded LTag and host cell proteins, and is known to be critical to LTag's ability to induce cellular transformation.
Compare File:5tct LTag DNA.png, showing the same protein bound to double-stranded DNA. Rendered from PDB ID 2H1L: Genes Dev. 2006 Sep 1;20(17):2373-82. Crystal structure of SV40 large T-antigen bound to p53: interplay between a viral oncoprotein and a cellular tumor suppressor. Lilyestrom W1, Klein MG, Zhang R, Joachimiak A, Chen XS. DOI: 10.1101/gad.1456306 PMID: 16951253 |
| Date | |
| Source | Own work |
| Author | Opabinia regalis |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 01:17, 18 February 2017 | | 1,200 × 1,200 (890 KB) | Opabinia regalis | {{Information |Description ={{en|1=The hexameric assembly of the SV40 polyomavirus large tumor antigen (LTag) zinc finger and helicase domains (rainbow) bound to the human tumor suppressor p53 (light blue). This interaction is one of several protein... |
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