File:180-TALEffectors TALEN.png
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Summary
| Description |
English: Space-filling drawing of an engineered TAL effector/nuclease bound to double-helical DNA. TALE proteins contain a series of alpha-helical hairpin domains, each of which binds an individual DNA base, so that the protein recognizes a long, very specific DNA sequence. This engineered construct attaches the specific FOK1 nuclease to one end of the TALE protein, and when two copies bind as a dimer the nuclease cleaves both strands of the DNA. Drawn by David Goodsell from PDB files 1FOK (nuclease/DNA) and 3UGM (TALE/DNA). |
| Date | |
| Source | RCSB PDB Molecule of the Month |
| Author | David Goodsell |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 14:35, 24 December 2014 | | 1,655 × 706 (782 KB) | Dcrjsr | User created page with UploadWizard |
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