File:ΔFosB accumulation.svg

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Summary

DescriptionΔFosB accumulation.svg	English: The top graph depicts the acute expression/induction of various Fos family proteins (i.e., c-Fos, FosB, ΔFosB, Fra1, and Fra2) in the D1-type medium spiny neurons of the nucleus accumbens following an acute/initial exposure to an addictive drug. The bottom graph depicts the accumulating expression of phosphorylated ΔFosB isoforms in the D1-type medium spiny neurons of the nucleus accumbens following repeated overdose on an addictive drug every 12 hours (upticks in expression occur at half-day intervals). The graph shows the very slow decline of the accumulated ΔFosB isoforms, which, in fact, persist for up to 2 months. Every line in this image was manually redrawn in inkscape to reflect the more-or-less identical graphs from the two sources listed below. Malenka RC, Nestler EJ, Hyman SE (2009) Sydor A, Brown RY , ed. Molecular Neuropharmacology: A Foundation for Clinical Neuroscience (2nd ed.), McGraw-Hill Medical, p. 110 ISBN: 9780071481274. "Figure 4–27" Nestler EJ, Barrot M, Self DW (September 2001). "DeltaFosB: a sustained molecular switch for addiction". Proc. Natl. Acad. Sci. U.S.A. 98 (20): 11042–11046. DOI:10.1073/pnas.191352698. PMID 11572966. PMC: 58680. "Figure 1"
Date	8 February 2015
Source	Own work based upon https://www.ncbi.nlm.nih.gov/pmc/articles/PMC58680/figure/F1
Author	Joseph Mickel (Seppi333)
Additional information InfoField	Note about this image's copyright/copyrightability: This SVG file might appear similar to the images in the sources above, but this image was not auto-traced from either source image in Inkscape. The relative height of the peaks of the curves (i.e., relative changes in gene expression) and horizontal spacing between them (i.e., the approximate times at which they occur), and the decay slope of the lines in the bottom graph were reproduced as accurately as possible using Figure 1 as a guide when this image was drawn. The spacing between the graphs, text placement within the graphs, and the axes, axis markers, and line/curve spacing were redrawn so as to vary from the original figure. Minor differences to the wording of some labels were also introduced in this file relative to the original. Per section 921 on the copyrightability of graphs, charts, tables, and figures from this publication by the US government Copyright Office, I'm not entirely sure these images are actually copyrightable; however, the aforementioned variations in this image relative to the original were introduced in the event that the the text and limited compilation of lines/curves within the images actually satisfy the minimum requiements for copyrightability. In other words, I (User:Seppi333) hold the copyright to this SVG version of the image, assuming it's actually copyrightable. I would prefer that the source images be linked or reused (in compliance with their copyright licensing terms) in place of this file whenever feasible or possible though since the depicted temporal variations in gene expression upon initial and repeated drug exposure are findings from Dr. Nestler's original research.
Related image files InfoField	■ File:ΔFosB.svg ■ File:Annotated ΔFosB.svg screenshot.png

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File history

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	Date/Time	Dimensions	User	Comment
current	07:12, 8 February 2015	400 × 440 (227 KB)	Seppi333	move line
	07:11, 8 February 2015	400 × 440 (227 KB)	Seppi333	move line
	06:58, 8 February 2015	400 × 440 (227 KB)	Seppi333	going for a massive column of uploads! (moving text leftward)
	06:57, 8 February 2015	400 × 440 (227 KB)	Seppi333	same as below
	06:56, 8 February 2015	400 × 440 (227 KB)	Seppi333	Reup: because svg check is down and inkscape sucks
	06:52, 8 February 2015	400 × 450 (227 KB)	Seppi333	User created page with UploadWizard