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FBXL7

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FBXL7
Identifiers
AliasesFBXL7, FBL6, FBL7, F-box and leucine-rich repeat protein 7, F-box and leucine rich repeat protein 7
External IDsOMIM: 605656; MGI: 3052506; HomoloGene: 69121; GeneCards: FBXL7; OMA:FBXL7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001278317
NM_012304

NM_176959

RefSeq (protein)

NP_001265246
NP_036436

NP_795933

Location (UCSC)Chr 5: 15.5 – 15.94 MbChr 15: 26.54 – 26.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

F-box/LRR-repeat protein 7 is a protein that in humans is encoded by the FBXL7 gene.[5][6][7]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination.

The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183580Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043556Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
  6. ^ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. Bibcode:1999CBio....9.1177C. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.
  7. ^ a b "Entrez Gene: FBXL7 F-box and leucine-rich repeat protein 7".

Further reading

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