Ectonucleoside triphosphate diphosphohydrolase 7

ENTPD7
Identifiers
Aliases	ENTPD7, LALP1, ectonucleoside triphosphate diphosphohydrolase 7
External IDs	OMIM: 616753; MGI: 2135885; HomoloGene: 122202; GeneCards: ENTPD7; OMA:ENTPD7 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	99,711,241 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	43,722,136 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; buccal mucosa cell; ; duodenum; ; mucosa of ileum; ; sperm; ; secondary oocyte; ; cartilage tissue; ; stromal cell of endometrium; ; mucosa of sigmoid colon; ; testicle;
	Top expressed in
	jejunum; ; pyloric antrum; ; duodenum; ; intestinal epithelium; ; cumulus cell; ; gastrula; ; epithelium of small intestine; ; motor neuron; ; intestinal villus; ; seminal vesicula;
	More reference expression data
	n/a
Gene ontology
Molecular function	hydrolase activity; metal ion binding; nucleoside-triphosphatase activity;
Cellular component	integral component of membrane; cytoplasmic vesicle membrane; membrane; cytoplasmic vesicle; endocytic vesicle membrane;
Biological process	nucleobase-containing small molecule catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	57089
	93685
	ENSG00000198018
	ENSMUSG00000025192
	Q9NQZ7
	Q3TCT4
	NM_020354; NM_001349962; NM_001349963
	NM_053103
	NP_065087; NP_001336891; NP_001336892
	NP_444333
	Wikidata
View/Edit Human	View/Edit Mouse

Ectonucleoside triphosphate diphosphohydrolase 7 is a protein that in humans is encoded by the ENTPD7 gene.^[5]

Function

This gene encodes a purine-converting ectoenzyme which belongs to the ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) family. The encoded protein hydrolyzes extracellular nucleoside triphosphates (UTP, GTP, and CTP) to nucleoside monophosphates as part of a purinergic signaling pathway. It contains two transmembrane domains at the N- and C-termini and a large, hydrophobic catalytic domain located in between. This gene affects oxidative stress as well as DNA damage and is a mediator of senescence. [provided by RefSeq, Mar 2017].

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198018 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025192 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Ectonucleoside triphosphate diphosphohydrolase 7". Retrieved 2018-05-11.