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Phillip Crews
Professor Phil Crews
Born (1943-08-15) August 15, 1943 (age 81)
Urbana, Illinois, U.S.
NationalityAmerican
OccupationChemist
Years active1969–present
SpousePeggy Crews

Phillip Crews (born August 15, 1943) is an African American chemist at UCSC. His research work is around marine natural products chemistry and diversity education in chemistry.[1] He was elected a Fellow of the American Association for the Advancement of Science in 2008.

Early life

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Crews was born in Champaign-Urbana, Illinois and lived in Chicago until the family moved to Palo Alto in the 1950s.[2] Crews attended Wilbur Junior High School and then Cubberley High School. He next attended UCLA, where he received a BS in chemistry and wrote the senior thesis: “Coupling constant mechanisms in 1H NMR”. He then received a PhD in chemistry at UCSB under Dominic J. Bertelli with a thesis titled “Chemistry of non-benzenoid aromatics”.[3] Crews then wrote and was awarded an NSF postdoctoral fellowship to investigate the stereochemistry of organo-metalloids at Princeton University with the late Kurt Mislow.[2][4]

Research

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Photo of Phil Crews on a boat in the late 1970s
On an early expedition in the late 1970’s to investigate the biosynthetic products of sponges

In 1970, Crews obtained a position in the chemistry department at UCSC, where he began his research career investigating physical organic chemistry.[1] In 1973 he shifted his research program towards the nascent area of marine natural products chemistry[5][6][7] as an untenured assistant professor.

Crews uses bioassay-guided isolation to discover natural products that may help treat or cure human diseases, incorporating elements of structure elucidation and employing state-of-the-art nuclear magnetic resonance (NMR) techniques.[8] He became especially interested in the molecular structures of the psymberins and the bengamides, molecules isolated from Indo-Pacific sponges.[2] Psymberin is one of his most important discoveries because of its potential for further development to treat solid tumor cancers. The mixed NRPS-PKS biosynthetic product comes from the marine sponge Psammocinia aff. Bulbosa. Crews research on psymberin has stimulated almost 100 studies and publications by other laboratories. Another molecule of importance is bengamide B, that led to an anti-cancer Phase I clinical trial on a close analog.[2] In addition to these two molecules, Crews has discovered many small molecule tools derived from marine sponges, some of which are used worldwide by research teams as molecular probes.  These small molecules include the actin inhibitors, jasplakinolide and latrunculin,[9] the Mitochondrial Complex I inhibitor, mycothiazole, the human methionine aminopeptidase inhibitor, and fascaplysins, an opioid receptor agonist. He is also a holder of a patent for oxazole anthelmintic agents of marine origin.[10] Crews led and co-authored of the widely-used textbook, “Organic Structure Analysis”.[11], along with Marcel Jaspars and Jaime Rodriguez. The first edition was published by Oxford University Press in 1998 and with the second edition being published in 2009. Crews' goal was to highlight the intense complexity of spectroscopic analysis of natural products, from which the “Crews rule” emerged. The “Crews rule” states that if a molecule’s ratio of hydrogens to carbons is less than 1, then additional measures should be performed to confirm the structure.[2]

In 1990 he became the principal investigator in the National Cooperative Drug Discovery Group (NCDDG) program.[12], a position he held for 20 years.[2] In 2017, he was honored with a special issue of the Journal of Natural Products.[2]

Diversity and outreach

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Crews has participated and led in numerous outreach programs,[13] including running the NIH-supported ACCESS program[14] for the past 27 years. This program helps first-generation and under-represented students from 2-year community colleges transition to 4-year university by giving them access to cutting edge research and building their confidence to continue in careers in science. His dedication to diversity and inclusion was recognized with UCSC's 2004 Excellence through Diversity Award.[15] He also gave the UCSC Spring 2019 Emeriti Lecture on “Inspirational Biomolecules from Oceania.”[16] In 2021, the UCSC chemistry department established the Phillip Crews symposium, "Powered by Chemistry, Strengthened by Diversity"[17] and student fellowship.

Winery

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In Crews’ early days in academia, Crews wanted to add a new dimension to chemical education at UCSC by contributing to the general education curriculum. He therefore launched of a new course, “Chemistry of wine - Introductory lecture-laboratory course for non-chemistry students”[18] as well as other lectures such as Wines & winemaking Merging Chemistry Fundamentals and Sensory Evaluation Outcomes to Gain a 21st Century Perspective at Cabrillo College.[8] This coursework, as well as his keen interest in wine, lead him to found Pelican Ranch Winery[19][20][21] with his wife Peggy (BW CA-W-3444) in 1997.

Awards and honors

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  • 1990 National Cooperative Drug Discovery Group (NCDDG) award[2]
  • 2004 The UCSC Excellence Through Diversity Award[15]
  • 2005 Arthur E. Schwarting Award, Journal of Natural Products[22]
  • 2008 Norman R Farnsworth American Society of Pharmacognosy Research Achievement Award[23]
  • 2008 Chair, Gordon Research Conference-Marine Natural Products, Ventura Beach, CA[24]
  • 2008 Elected Fellow of the American Association for the Advancement of Science[25]
  • 2009 Outstanding Faculty Award for the UC Santa Cruz Division of Physical and Biological Sciences[26]
  • 2012 American Society of Pharmacognosy Fellow[27]
  • 2014 American Society of Pharmacognosy President & Vice President[28]
  • 2015 Edward A. Dickson Endowed Professorship award[29]
  • 2017 Special Issue of Journal Natural Products in Honor of Professor Phil Crews[2]

References

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  1. ^ a b "Phillip O. Crews - Blackpast". January 29, 2007. Retrieved August 13, 2021.
  2. ^ a b c d e f g h i Cichewicz, Robert H.; Cragg, Gordon M.; Linington, Roger G.; Wright, Amy E. (2017). "Special Issue in Honor of Professor Phil Crews - ACS". Journal of Natural Products. 80 (3): 579–581. doi:10.1021/acs.jnatprod.7b00161. PMID 28335607.
  3. ^ Crews, Phillip (1961). "The question of aromaticity in non-benzenoid carbocycles : a re-evaluation of the mechanism for the silver catalyzed addition of benzyne to polyenes".
  4. ^ Rodríguez, Jaime; Crews, Phillip; Jaspars, Marcel (2012), Fattorusso, Ernesto; Gerwick, William H.; Taglialatela-Scafati, Orazio (eds.), "Contemporary Strategies in Natural Products Structure Elucidation", Handbook of Marine Natural Products, Dordrecht: Springer Netherlands, pp. 423–517, doi:10.1007/978-90-481-3834-0_7, ISBN 978-90-481-3834-0, retrieved October 21, 2022
  5. ^ Krajick, Kevin (April 30, 2004). "Medicine from the Sea: From slime to sponges, scientists are plumbing the ocean's depths for new medications to treat cancer, pain and other ailments". Smithsonian Magazine. Retrieved November 5, 2021.
  6. ^ BORG, JAMES C. (June 13, 1988). "Sea Cure : Scientists Enthusiastic About Potential Medical Compounds From Deep". Los Angeles Times. Retrieved November 5, 2021.
  7. ^ Petkewich, Rachel (May 2007). "Taking The Familiar Route: Pharma Still Has Room For Natural Products Chemists". Chemical and Engineering News. Retrieved November 5, 2021.
  8. ^ a b "Wines & winemaking Merging Chemistry Fundamentals and Sensory Evaluation Outcomes to Gain a 21st Century Perspective". Retrieved September 7, 2021.
  9. ^ Amagata, Taro; Johnson, Tyler A.; Cichewicz, Robert H.; Tenney, Karen; Mooberry, Susan L.; Media, Joseph; Edelstein, Matthew; Valeriote, Frederick A.; Crews, Phillip (November 27, 2008). "Interrogating the Bioactive Pharmacophore of the Latrunculin Chemotype by Investigating the Metabolites of Two Taxonomically Unrelated Sponges". Journal of Medicinal Chemistry. 51 (22): 7234–7242. doi:10.1021/jm8008585. ISSN 0022-2623. PMC 2772107. PMID 18942825.
  10. ^ "US Patent for Oxazole anthelmintic agents of marine origin". Retrieved November 5, 2021.
  11. ^ "Organic Structure Analysis - Hardcover - Phillip Crews; Jaime Rodriguez; Marcel Jaspars - Oxford University Press". global.oup.com. Retrieved August 12, 2021.
  12. ^ "National Cooperative Drug Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders, Drug or Alcohol Addiction (U19)". Retrieved November 5, 2021.
  13. ^ "Project 5-215 Indonesia". National Academies of Science, Engineering, and Medicine. Partnerships for Enhanced Engagement in Research (PEER). Retrieved November 5, 2021.
  14. ^ "A C C E S S :: Home". access.ucsc.edu. Retrieved August 12, 2021.
  15. ^ a b Donahue, Louise (June 24, 2004). "Awards honor 'excellence through diversity'". Retrieved August 13, 2021.
  16. ^ "Phil Crews Emeriti Lecture Apr 9, 2019". YouTube. Retrieved November 5, 2021.
  17. ^ "Phillip Crews Symposium: Powered by Chemistry, Strengthened by Diversity".
  18. ^ Crews, Phillip (1977). "The Chemistry of Wine. An Introductory Lecture--Laboratory Course for Nonchemistry Students". Journal of Chemical Education. 54 (10): 630. Bibcode:1977JChEd..54..630C. doi:10.1021/ED054P630. S2CID 95858110.
  19. ^ "CRUSH TIME AT PELICAN RANCH WINERY". KSQD Community Radio. Retrieved November 5, 2021.
  20. ^ "Pelican Ranch Winery | Premium Wines". Retrieved August 12, 2021.
  21. ^ Walker, Tara Fatemi (May 1, 2018). "Quick Bites: Wine futurology at Pelican Ranch Winery". Santa Cruz Sentinel. Retrieved November 5, 2021.
  22. ^ "Faculty Honors and Awards - UC Santa Cruz - Chemistry". Retrieved August 13, 2021.
  23. ^ Stephens, Tim (August 13, 2007). "Chemist Phil Crews earns Research Achievement Award". UC Santa Cruz Newsletter. Retrieved November 5, 2021.
  24. ^ "2008 Marine Natural Products Conference GRC". Retrieved August 13, 2021.
  25. ^ Stephens, Tim; Writer 459-2495, Staff. "Three UCSC professors elected AAAS Fellows". UC Santa Cruz News. Retrieved October 21, 2022.{{cite web}}: CS1 maint: numeric names: authors list (link)
  26. ^ Strain, Daniel (November 8, 2009). "Chemistry professor Phil Crews receives outstanding faculty award". Retrieved August 13, 2021.
  27. ^ "ASP Fellows". Retrieved November 5, 2021.
  28. ^ "Past Presidents of the ASP - The American Society of Pharmacognosy". Retrieved August 13, 2021.
  29. ^ Stephens, Tim (August 19, 2015). "Dickson Emeriti Professorship awarded to chemist Phil Crews".
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