Draft:LUZP2

Review waiting, please be patient.

This may take 6 weeks or more, since drafts are reviewed in no specific order. There are 1,215 pending submissions waiting for review.

If the submission is accepted, then this page will be moved into the article space.
If the submission is declined, then the reason will be posted here.
In the meantime, you can continue to improve this submission by editing normally.

Where to get help

If you need help editing or submitting your draft, please ask us a question at the AfC Help Desk or get live help from experienced editors. These venues are only for help with editing and the submission process, not to get reviews.
If you need feedback on your draft, or if the review is taking a lot of time, you can try asking for help on the talk page of a relevant WikiProject. Some WikiProjects are more active than others so a speedy reply is not guaranteed.

How to improve a draft

Wikipedia:Contributing to Wikipedia – a basic overview on how to edit Wikipedia.
Help:Wikitext – how to use the markup
Help:Referencing for beginners – how to include references
Wikipedia:Article development – how to develop your article
Wikipedia:Writing better articles – how to improve your article
Wikipedia:Verifiability – make sure your article includes reliable third-party sources

You can also browse Wikipedia:Featured articles and Wikipedia:Good articles to find examples of Wikipedia's best writing on topics similar to your proposed article.

Improving your odds of a speedy review

To improve your odds of a faster review, tag your draft with relevant WikiProject tags using the button below. This will let reviewers know a new draft has been submitted in their area of interest. For instance, if you wrote about a female astronomer, you would want to add the Biography, Astronomy, and Women scientists tags.

Add tags to your draft

Editor resources

Easy tools: Citation bot (help) | Advanced: Fix bare URLs

Reviewer tools

Instructions · What links here · LUZP2 (talk: + · bio) · (log) · Copyvios report · reFill · Citation Bot · (Search: Google, Wikipedia) · Submitted 8 days ago by Unicat1 (talk: D · +) · Last edited 7 days ago by Unicat1

LUZP2 is a protein-encoding gene that encodes for the leucine zipper protein 2^[1].

Gene

The LUZP2 gene is found on the short arm of chromosome 11 at position 11p14.3^[2]. It is located on the plus strand^[2]. Aliases for the protein include UNQ2566/PRO6246, PRO6246, FLJ45795 or KFSP2566, LOC338645^[3].

The gene contains 23 introns, and can produce 11 alternatively spliced mRNAs^[3].

Protein

LUZP2 encodes a leucine zipper protein that is 346 amino acids in length, and has a molecular weight of around 39 kDa^[4]. This protein is secreted, and is found mostly expressed within the brain and spinal cord^[1].

The protein contains a signal peptide, 3 glycosylation sites, 2 leucine zipper regions, and a disordered region^[4].

Clinical findings

Based on a data mining study investigating low-grade Gliomas, LUZP2 downregulation was found to be associated with higher-grade tumors, suggesting that LUZP2 expression decreased as tumors became more aggressive. Low LUZP2 expression was also associated with worse overall survival in patients with Low grade gliomas across multiple cohorts^[5].

This gene has also been found deleted in some patients with Wilms tumor-aniridia-ganomalies-mental retardation (WAGR) syndrome^[6].

Evolution

LUZP2 has no known paralogs, but has many orthologs in vertebrates. It is highly conserved in mammals, birds, and reptiles^[7].

LUZP2 is expected to have first appeared in cartilaginous fish around 462 million years ago, and is evolving at an intermediate rate, slower than fibrinogen alpha, but faster than cytochrome c.

References

^ ^a ^b "UniProt". www.uniprot.org. Retrieved 2024-10-12.
^ ^a ^b "Homo sapiens leucine zipper protein 2 (LUZP2), transcript variant 1, mRNA". National Library of Medicine. 2024-06-08.
^ ^a ^b "AceView: Gene:LUZP2, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView". www.ncbi.nlm.nih.gov. Retrieved 2024-10-12.
^ ^a ^b "leucine zipper protein 2 isoform 1 precursor [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-10-12.
^ Li, Yong; Deng, Gang; Qi, Yangzhi; Zhang, Huikai; Jiang, Hongxiang; Geng, Rongxin; Ye, Zhang; Liu, Baohui; Chen, Qianxue (2020-07-10). "Downregulation of LUZP2 Is Correlated with Poor Prognosis of Low-Grade Glioma". BioMed Research International. 2020: 1–16. doi:10.1155/2020/9716720. ISSN 2314-6133. PMC 7368956. PMID 32695826.
^ Wu, Min; Michaud, Edward J.; Johnson, Dabney K. (2003-05-01). "Cloning, functional study and comparative mapping of Luzp2 to mouse Chromosome 7 and human Chromosome 11p13–11p14". Mammalian Genome. 14 (5): 323–334. doi:10.1007/s00335-002-2248-6. ISSN 1432-1777. PMID 12856284.
^ "LUZP2 orthologs". NCBI. Retrieved 2024-10-13.

[:1-1] "UniProt". www.uniprot.org. Retrieved 2024-10-12.

[:0-2] "Homo sapiens leucine zipper protein 2 (LUZP2), transcript variant 1, mRNA". National Library of Medicine. 2024-06-08.

[:2-3] "AceView: Gene:LUZP2, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView". www.ncbi.nlm.nih.gov. Retrieved 2024-10-12.

[:3-4] "leucine zipper protein 2 isoform 1 precursor [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-10-12.

[5] Li, Yong; Deng, Gang; Qi, Yangzhi; Zhang, Huikai; Jiang, Hongxiang; Geng, Rongxin; Ye, Zhang; Liu, Baohui; Chen, Qianxue (2020-07-10). "Downregulation of LUZP2 Is Correlated with Poor Prognosis of Low-Grade Glioma". BioMed Research International. 2020: 1–16. doi:10.1155/2020/9716720. ISSN 2314-6133. PMC 7368956. PMID 32695826.

[6] Wu, Min; Michaud, Edward J.; Johnson, Dabney K. (2003-05-01). "Cloning, functional study and comparative mapping of Luzp2 to mouse Chromosome 7 and human Chromosome 11p13–11p14". Mammalian Genome. 14 (5): 323–334. doi:10.1007/s00335-002-2248-6. ISSN 1432-1777. PMID 12856284.

[7] "LUZP2 orthologs". NCBI. Retrieved 2024-10-13.

[1]

[2]

[3]

[4]

[5]

[6]

[7]