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Jacques Fellay

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Jacques Fellay
Fellay in 2020
Born
Orsières, Switzerland
NationalitySwiss
AwardsNational Latsis Prize (2012)
Leenaards Prize (2015)
Academic work
InstitutionsÉcole Polytechnique Fédérale de Lausanne (EPFL)
Websitehttps://fellay-lab.epfl.ch

Jacques Fellay (born 12 August 1974) is a Swiss medical doctor and researcher active in the fields of human genomics and infectious diseases. He is an associate professor at the École Polytechnique Fédérale de Lausanne, where he leads the laboratory of Human Genomics of Infection and Immunity.[1]

Career

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Fellay studied medicine in Fribourg, Lausanne and Vienna, and obtained his medical degree from the University of Lausanne in 2000. He then received an MD from the University of Lausanne and a PhD from Utrecht University. He was clinically trained in infectious diseases in Switzerland, before spending 4 years as a research scientist at Duke University. He joined the School of Life Sciences, EPFL in 2011.

Fellay is associate Professor in the School of Life Sciences, EPFL and at the University of Lausanne, founding director of the Precision Medicine Unit of the Lausanne University Hospital, group leader at the Swiss Institute of Bioinformatics, as well as co-director of the Health2030 Genome Center in Geneva.[2][3][4]

He is a member of the Swiss Federal Commission for Genetic Studies in Humans[5] and of the Swiss National COVID-19 Science Task Force.[6]

Research

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Fellay leads the laboratory of Human Genomics of Infection and Immunity at EPFL, which uses large-scale genomic approaches and bioinformatic tools to explore the impact of human genetic variation on infectious diseases, immune parameters and host-pathogen interactions. At the crossroad between basic biomedical science and the clinical world, his research aims at identifying the genomic factors modulating the human response to infectious and immune diseases, with the ultimate goal of offering novel diagnostic, preventative or therapeutic solutions customized to the unique genetic background of every patient.[7] His publications have led to the identification of genetic factors influencing host control and therapy response to viral infections such as HIV, Hepatitis C or respiratory diseases.[8][9][10][11][12][13][14][15][16]

Distinctions

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Fellay was awarded with the 2012 National Latsis Prize and the 2015 Leenaards Prize for translational medical research for his contributions to the better understanding of genetic susceptibility to HIV and Hepatitis C infections.[17][18][19][20][21]

He also received the Basic Research in Infectious Diseases Award in 2008 and 2017 from the Swiss Society for Infectious Diseases.[22]

References

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  1. ^ "Jacques Fellay's personal page at EPFL". epfl.ch. Retrieved 1 September 2020.
  2. ^ "Unité de médecine de précision du CHUV - Équipe". chuv.ch (in French). Retrieved 1 September 2020.
  3. ^ "Jacques Fellay's group at the SIB". sib.swiss. Retrieved 1 September 2020.
  4. ^ "For the public – Health2030 – Genome Center" (in French). Retrieved 1 September 2020.
  5. ^ BAG, Bundesamt für Gesundheit. "Eidgenössische Kommission für genetische Untersuchungen beim Menschen (GUMEK)". www.bag.admin.ch (in German). Retrieved 1 September 2020.
  6. ^ "ncs-tf.ch: Topics & Expert groups". ncs-tf.ch. Retrieved 1 September 2020.
  7. ^ "Fellay Lab – Human Genomics of Infection and Immunity". www.epfl.ch. Retrieved 1 September 2020.
  8. ^ Ge, Dongliang; Fellay, Jacques; Thompson, Alexander J.; Simon, Jason S.; Shianna, Kevin V.; Urban, Thomas J.; Heinzen, Erin L.; Qiu, Ping; Bertelsen, Arthur H.; Muir, Andrew J.; Sulkowski, Mark (September 2009). "Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance". Nature. 461 (7262): 399–401. Bibcode:2009Natur.461..399G. doi:10.1038/nature08309. ISSN 1476-4687. PMID 19684573. S2CID 1707096.
  9. ^ Fellay, Jacques; Shianna, Kevin V.; Ge, Dongliang; Colombo, Sara; Ledergerber, Bruno; Weale, Mike; Zhang, Kunlin; Gumbs, Curtis; Castagna, Antonella; Cossarizza, Andrea; Cozzi-Lepri, Alessandro (17 August 2007). "A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1". Science. 317 (5840): 944–947. Bibcode:2007Sci...317..944F. doi:10.1126/science.1143767. ISSN 0036-8075. PMC 1991296. PMID 17641165.
  10. ^ Fellay, Jacques; Thompson, Alexander J.; Ge, Dongliang; Gumbs, Curtis E.; Urban, Thomas J.; Shianna, Kevin V.; Little, Latasha D.; Qiu, Ping; Bertelsen, Arthur H.; Watson, Mark; Warner, Amelia (March 2010). "ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C". Nature. 464 (7287): 405–408. Bibcode:2010Natur.464..405F. doi:10.1038/nature08825. ISSN 1476-4687. PMID 20173735. S2CID 205219827.
  11. ^ McLaren, Paul J.; Coulonges, Cedric; Bartha, István; Lenz, Tobias L.; Deutsch, Aaron J.; Bashirova, Arman; Buchbinder, Susan; Carrington, Mary N.; Cossarizza, Andrea; Dalmau, Judith; Luca, Andrea De (24 November 2015). "Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load". Proceedings of the National Academy of Sciences. 112 (47): 14658–14663. Bibcode:2015PNAS..11214658M. doi:10.1073/pnas.1514867112. ISSN 0027-8424. PMC 4664299. PMID 26553974.
  12. ^ "Research effort reveals gene variants that play a role in HIV viral load in patients". medicalxpress.com. Retrieved 1 September 2020.
  13. ^ Hammer, Christian; Begemann, Martin; McLaren, Paul J.; Bartha, István; Michel, Angelika; Klose, Beate; Schmitt, Corinna; Waterboer, Tim; Pawlita, Michael; Schulz, Thomas F.; Ehrenreich, Hannelore; Fellay, Jacques (5 November 2015). "Amino Acid Variation in HLA Class II Proteins Is a Major Determinant of Humoral Response to Common Viruses". The American Journal of Human Genetics. 97 (5): 738–743. doi:10.1016/j.ajhg.2015.09.008. ISSN 0002-9297. PMC 4667104. PMID 26456283.
  14. ^ Goldsobel, Gady (12 October 2015). "Genetic variation is key to fighting viruses". Healthcanal.com. Retrieved 1 September 2020.
  15. ^ Asgari, Samira; Schlapbach, Luregn J.; Anchisi, Stéphanie; Hammer, Christian; Bartha, Istvan; Junier, Thomas; Mottet-Osman, Geneviève; Posfay-Barbe, Klara M.; Longchamp, David; Stocker, Martin; Cordey, Samuel (1 August 2017). "Severe viral respiratory infections in children with IFIH1 loss-of-function mutations". Proceedings of the National Academy of Sciences. 114 (31): 8342–8347. doi:10.1073/pnas.1704259114. ISSN 0027-8424. PMC 5547624. PMID 28716935.
  16. ^ "A gene increases the severity of common colds". 18 July 2017. Retrieved 1 September 2020.
  17. ^ "Jacques Fellay voudrait mieux connaître les vaches de ses patients". Le Temps (in French). 13 January 2013. ISSN 1423-3967. Retrieved 1 September 2020.
  18. ^ "Jacques Fellay receives the National Latsis Prize 2012 - SNF". www.snf.ch. Retrieved 1 September 2020.
  19. ^ Daugey, Fleur (December 2012). "Un chercheur qui a les pieds sur terre". Horizons (in French): 18–19.
  20. ^ "Génome contre génome : l'impact des variations génétiques humaines sur les infections virales chroniques". Fondation Leenaards - Favoriser la dynamique créatrice (in French). Retrieved 1 September 2020.
  21. ^ "Corpus - Radio". Play RTS (in French). 24 March 2015. Retrieved 1 September 2020.
  22. ^ "Awards & Fellows – Swiss Society for Infectious Diseases". www.sginf.ch. Retrieved 1 September 2020.


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