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Anatoly B. Kolomeisky

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Anatoly Boris Kolomeisky (Russian Анатолий Коломейский) (September 3, 1967) is a professor of Chemistry, Chemical and Biomolecular Engineering, Physics and Astronomy and chairman of the department of Chemistry at Rice University in Houston, Texas.

Kolomeisky specializes in theoretical chemistry and theoretical biophysics using methods of statistical mechanics.

Early life and education

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Born in Vinnitsa (Ukraine) in what was the Soviet Union, Kolomeisky received his M.Sc. (with honors) in Chemistry from Moscow State University in 1991. In 1992 Kolomeisky went to the United States, where he attended the University of Kentucky (1993-1994) and then Cornell University in 1994 for his graduate studies.

Kolomeisky obtained his Ph.D. (summa cum laude) from Cornell in 1998 working under supervision of Professor Ben Widom. Kolomeisky's Ph.D. research focused on theoretical investigations of one-dimensional stochastic models for studying various biological and chemical processes.[1]

Career

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After completing his Ph.D. in 1998, he joined the group of Prof. Michael E. Fisher at University of Maryland at College Park as a postdoctoral research associate. Working there, Kolomeisky became involved in a variety of theoretical investigations on mechanisms of complex physical, chemical and biological systems.

Kolomeisky developed a lattice version of Debye-Huckel theory for electrolytes,[2] and he also developed a first theoretical description of the force generation mechanisms by motor proteins and biological molecular motors.[3] In 2000 Kolomeisky joined Department of Chemistry at Rice University as an Assistant Professor and he became a Full Professor there in 2011. In 2018 Kolomeisky became the Department Chair of Chemistry at Rice and in 2019 added a joint appointment with department of Physics and Astronomy.[1]

Research

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Kolomeisky leads a multi-disciplinary research group focused on theoretical modeling of complex physical, chemical and biological processes using methods of statistical mechanics. He investigated in detail the dynamic properties of one-dimensional asymmetric simple exclusion processes (ASEP) and applied it for various systems [4] Kolomeisky, together with experimental collaborators, also intensively studied the molecular transport through channels and nanopores [5]

In addition, Kolomeisky developed a new theoretical framework for analyzing dynamics of protein-DNA interactions.[6] Furthermore, Kolomeisky was actively involved in theoretical studies of the formation of morphogen gradients in biological signaling systems,[7] of the genome interrogation by CRISPR systems,[8] understanding mechanisms of biological error correction,[9] investigations of the mechanisms of cytoskeleton protein filaments dynamics, and the [10] dynamics of cancer formation.[11]

Kolomeisky co-authored more than 210 publications, 9 invited review papers and 5 book chapters. In 2015 he wrote a book "Motor Proteins in Molecular Motors."[12] He is currently the editor of the Biophysical Journal. He also served as a guest editor for Journal of Physics: Condensed Matter.

Awards and honors

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Kolomeisky received a Humboldt Research Fellowship for Experienced Scientists in 2008.[1] In 2015 he was elected a Fellow of the American Physical Society for "major advances in the field of theoretical biophysics by fundamental contributions to the understanding of the mechanisms of motor proteins, cytoskeleton dynamics, protein nucleation, channel transport, and protein-DNA interactions."[13]

References

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  1. ^ a b c "Curriculum Vitae - Anatoly B. Kolomeisky" (PDF). Rice University. Retrieved 31 March 2020.
  2. ^ Kobelev, Vladimir; Kolomeisky, Anatoly B.; Fisher, Michael E. (2002). "Lattice models of ionic systems". The Journal of Chemical Physics. 116 (17). AIP Publishing: 7589–7598. arXiv:cond-mat/0112238. Bibcode:2002JChPh.116.7589K. doi:10.1063/1.1464827. ISSN 0021-9606. S2CID 6327394.
  3. ^ Kolomeisky, Anatoly B.; Fisher, Michael E. (2007). "Molecular Motors: A Theorist's Perspective". Annual Review of Physical Chemistry. 58 (1). Annual Reviews: 675–695. Bibcode:2007ARPC...58..675K. doi:10.1146/annurev.physchem.58.032806.104532. ISSN 0066-426X. PMID 17163836.
  4. ^ Kolomeisky, Anatoly B; Schütz, Gunter M; Kolomeisky, Eugene B; Straley, Joseph P (1998-08-21). "Phase diagram of one-dimensional driven lattice gases with open boundaries". Journal of Physics A: Mathematical and General. 31 (33). IOP Publishing: 6911–6919. Bibcode:1998JPhA...31.6911K. doi:10.1088/0305-4470/31/33/003. ISSN 0305-4470.
  5. ^ Kolomeisky, Anatoly B. (2007-01-26). "Channel-Facilitated Molecular Transport across Membranes: Attraction, Repulsion, and Asymmetry". Physical Review Letters. 98 (4). American Physical Society (APS): 048105. arXiv:cond-mat/0610086. Bibcode:2007PhRvL..98d8105K. doi:10.1103/physrevlett.98.048105. ISSN 0031-9007. PMID 17358819. S2CID 14371039.
  6. ^ Kinetics of Protein-DNA Interactions: First-Passage Analysis (M.P. Kochugaeva, A.A. Shvets and A,B. Kolomeisky), in ”Chemical Kinetics beyond the Textbook”, Ed.: K. Lindenberg, R. Metzler, G. Oshanin, World Scientific, 2018.
  7. ^ Teimouri, Hamid; Kolomeisky, Anatoly B (2016-11-07). "Mechanisms of the formation of biological signaling profiles". Journal of Physics A: Mathematical and Theoretical. 49 (48). IOP Publishing: 483001. Bibcode:2016JPhA...49V3001T. doi:10.1088/1751-8113/49/48/483001. ISSN 1751-8113. S2CID 54715515.
  8. ^ Shvets, Alexey A.; Kolomeisky, Anatoly B. (2017). "Mechanism of Genome Interrogation: How CRISPR RNA-Guided Cas9 Proteins Locate Specific Targets on DNA". Biophysical Journal. 113 (7). Elsevier BV: 1416–1424. Bibcode:2017BpJ...113.1416S. doi:10.1016/j.bpj.2017.08.013. ISSN 0006-3495. PMC 5627312. PMID 28978436.
  9. ^ Banerjee, Kinshuk; Kolomeisky, Anatoly B.; Igoshin, Oleg A. (2017-05-02). "Elucidating interplay of speed and accuracy in biological error correction". Proceedings of the National Academy of Sciences. 114 (20): 5183–5188. doi:10.1073/pnas.1614838114. ISSN 0027-8424. PMC 5441828. PMID 28465435.
  10. ^ Li, Xin; Kolomeisky, Anatoly B. (2015-03-23). "The Role of Multifilament Structures and Lateral Interactions in Dynamics of Cytoskeleton Proteins and Assemblies". The Journal of Physical Chemistry B. 119 (13). American Chemical Society (ACS): 4653–4661. doi:10.1021/acs.jpcb.5b01219. hdl:1911/80752. ISSN 1520-6106. PMID 25768280.
  11. ^ Teimouri, Hamid; Kochugaeva, Maria P.; Kolomeisky, Anatoly B. (2019). "Elucidating the correlations between cancer initiation times and lifetime cancer risks". Scientific Reports. 9 (1). Springer Science and Business Media LLC: 18940. Bibcode:2019NatSR...918940T. doi:10.1038/s41598-019-55300-w. ISSN 2045-2322. PMC 6908632. PMID 31831779.
  12. ^ “Motor Proteins and Molecular Motors,” (A.B. Kolomeisky), CRC Press, Taylor and Francis, 2015.
  13. ^ "APS Fellow Archive". American Physical Society. Retrieved 31 March 2020.
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