5α-Dihydrocortisol
Appearance
(Redirected from Dihydrocortisol)
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IUPAC name
11β,17α,21-Trihydroxy-5α-pregnane-3,20-dione
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Systematic IUPAC name
(1R,3aS,3bS,5aS,9aS,9bS,10S,11aS)-1,10-Dihydroxy-1-(hydroxyacetyl)-9a,11a-dimethylhexadecahydro-7H-cyclopenta[a]phenanthren-7-one | |
Other names
Hydrallostane; 5α-DHF; Allodihydrocortisol
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Identifiers | |
3D model (JSmol)
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PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C21H32O5 | |
Molar mass | 364.482 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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5α-Dihydrocortisol (5α-DHF), also known as hydrallostane or as allodihydrocortisol,[1] is a metabolite of cortisol that is formed by 5α-reductase.[2][3] It is present in the aqueous humor of the eye, is produced in the lens of the eye, and is involved in regulating the formation of the aqueous humor.[2] 5α-DHF can be further metabolized into 3α,5α-tetrahydrocortisol by 3α-hydroxysteroid dehydrogenase.[3]
References
[edit]- ^ "Hydrallostane".
- ^ a b Azzouni F, Godoy A, Li Y, Mohler J (2012). "The 5 alpha-reductase isozyme family: a review of basic biology and their role in human diseases". Adv Urol. 2012: 530121. doi:10.1155/2012/530121. PMC 3253436. PMID 22235201.
- ^ a b Wilson JD (2001). "The role of 5alpha-reduction in steroid hormone physiology". Reprod. Fertil. Dev. 13 (7–8): 673–8. doi:10.1071/RD01074. PMID 11999320.