HCST (gene)

HCST
Identifiers
Aliases	HCST, DAP10, KAP10, PIK3AP, hematopoietic cell signal transducer
External IDs	OMIM: 604089; MGI: 1344360; HomoloGene: 8024; GeneCards: HCST; OMA:HCST - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.12 Start 35,902,529 bp End 35,904,377 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 B1|7 17.45 cM Start 30,117,137 bp End 30,119,279 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte bone marrow blood bone marrow cells spleen appendix lymph node thymus trabecular bone Top expressed in granulocyte thymus tibiofemoral joint blood spleen mesenteric lymph nodes embryo embryo duodenum right kidney More reference expression data BioGPS n/a
Gene ontology Molecular function signaling receptor binding protein binding phosphatidylinositol 3-kinase binding Cellular component integral component of membrane cell surface plasma membrane membrane Biological process protein phosphorylation regulation of immune response positive regulation of phosphatidylinositol 3-kinase signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10870 23900 Ensembl ENSG00000126264 ENSMUSG00000064109 UniProt Q9UBK5 Q9QUJ0 RefSeq (mRNA) NM_014266 NM_001007469 NM_011827 RefSeq (protein) NP_001007470 NP_055081 NP_035957 Location (UCSC) Chr 19: 35.9 – 35.9 Mb Chr 7: 30.12 – 30.12 Mb PubMed search
Wikidata
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Hematopoietic cell signal transducer is a protein that in humans is encoded by the HCST gene.

This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms.

Further reading

• Karimi M, Cao TM, Baker JA, et al. (2006). "Silencing human NKG2D, DAP10, and DAP12 reduces cytotoxicity of activated CD8+ T cells and NK cells". J. Immunol. 175 (12): 7819–28. doi:10.4049/jimmunol.175.12.7819. PMID 16339517.
• André P, Castriconi R, Espéli M, et al. (2004). "Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors". Eur. J. Immunol. 34 (4): 961–71. doi:10.1002/eji.200324705. PMID 15048706.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Billadeau DD, Upshaw JL, Schoon RA, et al. (2003). "NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway". Nat. Immunol. 4 (6): 557–64. doi:10.1038/ni929. PMID 12740575. S2CID 7699074.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Diefenbach A, Tomasello E, Lucas M, et al. (2002). "Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D". Nat. Immunol. 3 (12): 1142–9. doi:10.1038/ni858. PMID 12426565. S2CID 14901451.
• Gilfillan S, Ho EL, Cella M, et al. (2002). "NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation". Nat. Immunol. 3 (12): 1150–5. doi:10.1038/ni857. PMID 12426564. S2CID 5859797.
• Yim D, Jie HB, Sotiriadis J, et al. (2001). "Molecular cloning and characterization of pig immunoreceptor DAP10 and NKG2D". Immunogenetics. 53 (3): 243–9. doi:10.1007/s002510100321. PMID 11398969. S2CID 23708388.
• Cosman D, Müllberg J, Sutherland CL, et al. (2001). "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor". Immunity. 14 (2): 123–33. doi:10.1016/S1074-7613(01)00095-4. PMID 11239445.
• Wu J, Cherwinski H, Spies T, et al. (2000). "DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells". J. Exp. Med. 192 (7): 1059–68. doi:10.1084/jem.192.7.1059. PMC 2193316. PMID 11015446.
• Chang C, Dietrich J, Harpur AG, et al. (1999). "Cutting edge: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties". J. Immunol. 163 (9): 4651–4. doi:10.4049/jimmunol.163.9.4651. PMID 10528161.