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Cheng-Ming Chuong

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Cheng Ming Chuong,
鍾正明
Born (1952-09-15) September 15, 1952 (age 72)
Taipei, Taiwan
CitizenshipAmerican
Alma materNational Taiwan University (MD)
Rockefeller University (PhD)
Scientific career
FieldsBiomedical science
InstitutionsUniversity of Southern California

Cheng-Ming Chuong (Chinese: 鍾正明; born 1952) is a Taiwanese-American biomedical scientist.[1]

Education and personal life

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He is a professor of pathology in University of Southern California, and academician of Academia Sinica in Taiwan.[1] Chuong grew up in Taipei, Taiwan, and graduated from Department of Medicine, Taiwan University in 1978.[2] He then went to the Rockefeller University to pursue Ph.D. degree, where he studied neural cell adhesion molecules and pattern formation with Gerald M. Edelman.[2] He received Ph.D. in 1983, and stayed as an assistant professor in the Rockefeller University till 1987.[2] With Edelman, he worked on identifying neural cell adhesion molecules and pattern formation in the brain.[3]

Career and research

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He moved to the University of Southern California in 1987 and is currently a professor.[1] Chuong directs the Laboratory of Tissue Development and Engineering in the Department of Pathology, USC.[2] Using skin appendages as the experimental model, his team has studied how skin appendages undergo cyclic renewal and how these progenitor cells are guided to form specific tissue patterns and organ architectures in development, regeneration and evolution.[4] The research of his laboratory has been supported by National Institute of Health since 1988.[4][5]

He uses skin appendages as an experimental model and studies their organizing principles.[2] He has particularly focused on feather morphogenesis.[1] In 1998, he edited a book on “Epithelial Appendage Morphogenesis: Variations of a common theme and implications in regeneration“.[5] In 2003, he edited a special issue on the evolution and development of Integument with Dominique G. Homberger.[6] In 2009, he edited another special issue with Michael K. Richardson on Pattern Formation.[7] In 2016, he published an essay on “The Tao of integuments” in Science.[8] He is mostly notable for:

Tissue patterning in the developing skin. In 1998, Chuong’s laboratory showed how FGF/BMP fulfills Turing activator / inhibitor criteria in feather periodic pattern formation.[9] In 1999, they demonstrated self-organizing process in skin explants using dissociated dermal cells.[10] They further showed the assembly of dermal muscle network via mechanical force to build complex tissue patterning in the skin.[11]

Building region-specific feathers. Chuong’s laboratory set up a model to study feather follicle which allows them to identify feather stem cells and molecular circuits involved in forming radially symmetric, bilaterally symmetric, and bilaterally asymmetric feathers, as well as barb branch types (feather vane vs fluffy branches) from the proximal to distal feather.[12] In 2019, they publish a comprehensive paper on the bio-architecture and adaptation of flight feathers.[10] In addition to feather forms, they demonstrate melanocyte stem cells in feather follicles and how they form within-a-feather color patterns and how beta keratin gene clusters use a novel strategy for gene cluster regulation.[13][14]

Reveal collective regenerative behavior in a hair follicle population. Chuong’s team demonstrated intra-dermal adipose tissue exhibits BMP cycling which is out of phase with epidermal beta-catenin cycling in hair follicles.[15] Further, the intra-dermal adipose BMP remains high during pregnancy and lactation to maintain hairs for nursing.[16] These findings led to the concept that the extra-follicular macro-environment such as hormones, seasons, aging, can also modulate hair follicle stem cell activity.[17] They developed Cellular Automata model to describe this temporal patterning process.[18] Based on these, with topologically well-positioned hair plucking, they demonstrated an organ level quorum sensing process which can be hair regeneration more than those plucked.[19] Furthermore, they showed that tissue rigidity is involved in wound induced follicle neogenesis and can be modulated to enhance Turing periodic patterning process for de novo hair regeneration.[20] With these achievements, they are able to build reconstituted skin from dissociated progenitor cells for regenerative engineering.[10][21]

Evo-Devo of integumentary organs. In addition to the micro-evolution, which is the modification of organ shape, size, such as those seen in feathers, beaks, or tooth, Chuong’s team worked on the macro-evolution mechanisms by converting scales into feathers.[22] They demonstrated the different regenerative mechanism of three different integumentary follicle types, hair, feather, and tooth.[23] Chuong also works with paleontologists on Mesozoic feathers.[24] The "Birth of Birds" was chosen as one of the 10 breakthroughs in 2014 by Science.[25]

Honors and awards

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1988: American Cancer Society Junior Faculty Research Award[26]

1991: Robert Cleland Teaching Award[27]

1992: Zumberg Fellow, University of Southern California[citation needed]

1994: Robert Cleland Teaching Award, University of Southern California[27]

2000: John Ebbling Lecture, European Hair Research Society[28]

2002: Don Orwin Lecture, Australia[27]

2004: Riken symposium, Japan[27]

2006: Associates Award for Creativity in Research, Univ. Southern California[29]

2006: Saxén Medal awardee, Sigrid Juselius International Symposium, Finland[27]

2008: Elected to Academician, Academia Sinica, Taiwan (Taiwan National Academy)[4]

2013: Keynote, Japan Developmental Biology Society[27]

2014: Keynote, Korea Soc. Invest. Dermatology[27]

2014: A review contributing to “Birth of birds” as one of the 10 breakthroughs by Science[30]

2015: Elected to American Association for the Advancement of Science as a fellow[31]

2016: Kligman/Frost Leadership Award, Soc. Investigative Dermatology[32]

2018: Keynote, American Hair Research Summit[33]

2018: Keynote, Taiwan Society for Developmental Biology[34]

2020: NIH R37 MERIT award status, “Tissue patterning in living skin and explant cultures”[35]

2021: Plenary talk, Am Association for Anatomy, annual meeting in Exp. Biology

Chuong has served as associated editors and in editorial boards in major developmental biology and dermatology journals.[36][37] His grant on tissue patterning is awarded MERIT status in 2020.[4]

He became honorary distinguished research professor of National Taiwan University, Taipei Medical University and several other major universities in Taiwan.[38][39] He helps set up Integrative Evolutionary Galliform Genomics (iEGG) in National Chung Hsing University,[13] International Wound Repair and Regenerative Center (iWRR) in National Cheng Kung University,[1] and Integrative Stem Cell Center for China Medical University in Taiwan.[38] He has helped organize stem cells, biomimetics, and avian model systems meeting in Taiwan.[40]

References

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  1. ^ a b c d e "Cheng-Ming Chuong, MD, PhD | Keck School of Medicine of USC". 31 July 2018. Retrieved 2021-11-08.
  2. ^ a b c d e "ORCID". orcid.org. Retrieved 2021-11-08.
  3. ^ "Cheng-Ming Chuong | USC Profiles". profiles.sc-ctsi.org. Retrieved 2021-11-08.
  4. ^ a b c d "Laboratory of Tissue Development and Regeneration". sites.usc.edu. Retrieved 2021-11-08.
  5. ^ a b Chuong, Cheng-Ming (2013). Morphogenesis of Epithelial Appendages: Variations on Top of a Common Theme and Implications in Regeneration. Landes Bioscience.
  6. ^ Chuong, Cheng Ming; Homberger, Dominique G. (2003-08-15). "Development and Evolution of the Amniote Integument: Current Landscape and Future Horizon". Journal of Experimental Zoology Part B: Molecular and Developmental Evolution. 298 (1): 1–11. doi:10.1002/jez.b.23. PMC 4386659. PMID 12949766.
  7. ^ Chuong, Cheng-Ming; Richardson, Michael K. (2009). "Pattern formation today". The International Journal of Developmental Biology. 53 (5–6): 653–658. doi:10.1387/ijdb.082594cc. ISSN 1696-3547. PMC 2874132. PMID 19557673.
  8. ^ Lai, Yung Chih; Chuong, Cheng-Ming (2016-12-23). "The "tao" of integuments". Science. 354 (6319): 1533–1534. Bibcode:2016Sci...354.1533L. doi:10.1126/science.aal4572. ISSN 0036-8075. PMC 5548694. PMID 28008029.
  9. ^ Jung, H. S.; Francis-West, P. H.; Widelitz, R. B.; Jiang, T. X.; Ting-Berreth, S.; Tickle, C.; Wolpert, L.; Chuong, C. M. (1998-04-01). "Local inhibitory action of BMPs and their relationships with activators in feather formation: implications for periodic patterning". Developmental Biology. 196 (1): 11–23. doi:10.1006/dbio.1998.8850. ISSN 0012-1606. PMID 9527877.
  10. ^ a b c "Laboratory of Tissue Development and Regeneration". sites.usc.edu. Retrieved 2021-11-12.
  11. ^ Wu, Xiao-Shan; Yeh, Chao-Yuan; Harn, Hans I.-Chen; Jiang, Ting-Xing; Wu, Ping; Widelitz, Randall B.; Baker, Ruth E.; Chuong, Cheng-Ming (2019-05-28). "Self-assembly of biological networks via adaptive patterning revealed by avian intradermal muscle network formation". Proceedings of the National Academy of Sciences of the United States of America. 116 (22): 10858–10867. doi:10.1073/pnas.1818506116. ISSN 1091-6490. PMC 6561168. PMID 31072931.
  12. ^ Jiang, T. X.; Jung, H. S.; Widelitz, R. B.; Chuong, C. M. (1999). "Self-organization of periodic patterns by dissociated feather mesenchymal cells and the regulation of size, number and spacing of primordia". Development. 126 (22): 4997–5009. doi:10.1242/dev.126.22.4997. ISSN 0950-1991. PMID 10529418.
  13. ^ a b Chang, Wei-Ling; Wu, Hao; Chiu, Yu-Kun; Wang, Shuo; Jiang, Ting-Xin; Luo, Zhong-Lai; Lin, Yen-Cheng; Li, Ang; Hsu, Jui-Ting; Huang, Heng-Li; Gu, How-Jen (2019-11-27). "The Making of a Flight Feather: Bio-architectural Principles and Adaptation". Cell. 179 (6): 1409–1423.e17. doi:10.1016/j.cell.2019.11.008. ISSN 1097-4172. PMC 6953487. PMID 31778655.
  14. ^ Liang, Ya-Chen; Wu, Ping; Lin, Gee-Way; Chen, Chih-Kuan; Yeh, Chao-Yuan; Tsai, Stephanie; Yan, Jie; Jiang, Ting-Xin; Lai, Yung-Chih; Huang, David; Cai, Mingyang (2020-06-08). "Folding Keratin Gene Clusters during Skin Regional Specification". Developmental Cell. 53 (5): 561–576.e9. doi:10.1016/j.devcel.2020.05.007. ISSN 1878-1551. PMC 7386462. PMID 32516596.
  15. ^ Plikus, Maksim V.; Mayer, Julie Ann; de la Cruz, Damon; Baker, Ruth E.; Maini, Philip K.; Maxson, Robert; Chuong, Cheng-Ming (2008-01-17). "Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration". Nature. 451 (7176): 340–344. Bibcode:2008Natur.451..340P. doi:10.1038/nature06457. ISSN 1476-4687. PMC 2696201. PMID 18202659.
  16. ^ Chuong, Cheng-Ming; Randall, Valerie A; Widelitz, Randall B.; Wu, Ping; Jiang, Ting-Xin (2012). "Physiological regeneration of skin appendages and implications for regenerative medicine". Physiology. 27 (2): 61–72. doi:10.1152/physiol.00028.2011. ISSN 1548-9213. PMC 3620028. PMID 22505663.
  17. ^ Chen, Chih-Chiang; Murray, Philip J.; Jiang, Ting Xin; Plikus, Maksim V.; Chang, Yun-Ting; Lee, Oscar K.; Widelitz, Randall B.; Chuong, Cheng-Ming (2014-08-01). "Regenerative Hair Waves in Aging Mice and Extra-Follicular Modulators Follistatin, Dkk1, and Sfrp4". Journal of Investigative Dermatology. 134 (8): 2086–2096. doi:10.1038/jid.2014.139. ISSN 0022-202X. PMC 4102635. PMID 24618599.
  18. ^ Plikus, Maksim V.; Baker, Ruth E.; Chen, Chih-Chiang; Fare, Clyde; de la Cruz, Damon; Andl, Thomas; Maini, Philip K.; Millar, Sarah E.; Widelitz, Randall; Chuong, Cheng-Ming (2011-04-29). "Self-organizing and stochastic behaviors during the regeneration of hair stem cells". Science. 332 (6029): 586–589. Bibcode:2011Sci...332..586P. doi:10.1126/science.1201647. ISSN 1095-9203. PMC 3321266. PMID 21527712.
  19. ^ Chen, Chih-Chiang; Wang, Lei; Plikus, Maksim V.; Jiang, Ting Xin; Murray, Philip J.; Ramos, Raul; Guerrero-Juarez, Christian F.; Hughes, Michael W.; Lee, Oscar K.; Shi, Songtao; Widelitz, Randall B. (2015-04-09). "Organ-level quorum sensing directs regeneration in hair stem cell populations". Cell. 161 (2): 277–290. doi:10.1016/j.cell.2015.02.016. ISSN 1097-4172. PMC 4393531. PMID 25860610.
  20. ^ Harn, Hans I.-Chen; Wang, Sheng-Pei; Lai, Yung-Chih; Van Handel, Ben; Liang, Ya-Chen; Tsai, Stephanie; Schiessl, Ina Maria; Sarkar, Arijita; Xi, Haibin; Hughes, Michael; Kaemmer, Stefan (2021-05-10). "Symmetry breaking of tissue mechanics in wound induced hair follicle regeneration of laboratory and spiny mice". Nature Communications. 12 (1): 2595. Bibcode:2021NatCo..12.2595H. doi:10.1038/s41467-021-22822-9. ISSN 2041-1723. PMC 8110808. PMID 33972536.
  21. ^ Lei, Mingxing; Schumacher, Linus J.; Lai, Yung-Chih; Juan, Wen-Tau; Yeh, Chao-Yuan; Wu, Ping; Jiang, Ting-Xin; Baker, Ruth E.; Widelitz, Randall Bruce; Yang, Li; Chuong, Cheng-Ming (2017-08-22). "Self-organization process in newborn skin organoid formation inspires strategy to restore hair regeneration of adult cells". Proceedings of the National Academy of Sciences of the United States of America. 114 (34): E7101–E7110. doi:10.1073/pnas.1700475114. ISSN 1091-6490. PMC 5576784. PMID 28798065.
  22. ^ Wu, Ping; Yan, Jie; Lai, Yung-Chih; Ng, Chen Siang; Li, Ang; Jiang, Xueyuan; Elsey, Ruth M.; Widelitz, Randall; Bajpai, Ruchi; Li, Wen-Hsiung; Chuong, Cheng-Ming (2018-02-01). "Multiple Regulatory Modules Are Required for Scale-to-Feather Conversion". Molecular Biology and Evolution. 35 (2): 417–430. doi:10.1093/molbev/msx295. ISSN 1537-1719. PMC 5850302. PMID 29177513.
  23. ^ Wu, Ping; Wu, Xiaoshan; Jiang, Ting-Xin; Elsey, Ruth M.; Temple, Bradley L.; Divers, Stephen J.; Glenn, Travis C.; Yuan, Kuo; Chen, Min-Huey; Widelitz, Randall B.; Chuong, Cheng-Ming (2013-05-28). "Specialized stem cell niche enables repetitive renewal of alligator teeth". Proceedings of the National Academy of Sciences of the United States of America. 110 (22): E2009–2018. Bibcode:2013PNAS..110E2009W. doi:10.1073/pnas.1213202110. ISSN 1091-6490. PMC 3670376. PMID 23671090.
  24. ^ Xu, Xing; Zhou, Zhonghe; Dudley, Robert; Mackem, Susan; Chuong, Cheng-Ming; Erickson, Gregory M.; Varricchio, David J. (2014-12-12). "An integrative approach to understanding bird origins". Science. 346 (6215): 1253293. doi:10.1126/science.1253293. ISSN 1095-9203. PMID 25504729. S2CID 24228777.
  25. ^ Pennisi, E.; Kaiser, J.; Service, R. F.; Gibbons, A.; Vogel, G.; Underwood, E.; Hand, E. (2014-12-19). "Runners-up". Science. 346 (6216): 1444–1449. doi:10.1126/science.346.6216.1444. PMID 25525224.
  26. ^ Chuong, Cheng-Ming; Chen, Hai-Ming; Jiang, Ting-Xing; Chia, Jennifer (1991). "Adhesion Molecules in Skin Development: Morphogenesis of Feather and Haira". Annals of the New York Academy of Sciences. 642 (1): 263–280. Bibcode:1991NYASA.642..263C. doi:10.1111/j.1749-6632.1991.tb24393.x. ISSN 1749-6632. PMID 1809086. S2CID 15997832.
  27. ^ a b c d e f g "Cheng Ming Chuong" (PDF). www.phys.sinica.edu.tw. Retrieved 8 November 2021.
  28. ^ Yu, Mingke; Wu, Ping; Widelitz, Randall B.; Chuong, Cheng-Ming (2002-11-21). "The morphogenesis of feathers". Nature. 420 (6913): 308–312. Bibcode:2002Natur.420..308Y. doi:10.1038/nature01196. PMC 4386656. PMID 12442169.
  29. ^ "USC Associates Awards". USC Provost. Retrieved 2021-11-08.
  30. ^ "Avian Model Systems 9". Avian Model Systems 9. Retrieved 2021-11-08.
  31. ^ "USC Stem Cell researcher Cheng-Ming Chuong named fellow of national science association". USC Stem Cell. 14 December 2014. Retrieved 2021-11-08.
  32. ^ user (2015-09-19). "606. Cheng-Ming Chuong 鍾正明 / 2015/09". History of Taiwanese American (T.A. Archives) 台美史料中心. Retrieved 2021-11-08. {{cite web}}: |last= has generic name (help)
  33. ^ Plikus, Maksim V.; Widelitz, Randall B.; Maxson, Rob; Chuong, Cheng-Ming (2009). "Analyses of regenerative wave patterns in adult hair follicle populations reveal macro-environmental regulation of stem cell activity". The International Journal of Developmental Biology. 53 (5–6): 857–868. doi:10.1387/ijdb.072564mp. ISSN 0214-6282. PMC 2759942. PMID 19378257.
  34. ^ "深入生技". twbiogroup.org (in Chinese). Retrieved 2021-11-08.
  35. ^ Chuong, Cheng-Ming. "Tissue Patterning in living skin and organ ex". {{cite journal}}: Cite journal requires |journal= (help)
  36. ^ "Editors / Editorial Board". Arbeitsgemeinschaft Dermatologische Forschung. Retrieved 2021-11-08.
  37. ^ "Editors | Scientific Reports". www.nature.com. Retrieved 2021-11-08.
  38. ^ a b "Integrative Stem Cell Center | Excellence". 中國醫藥大學附設醫院 (in Traditional Chinese). Retrieved 2021-11-08.
  39. ^ "National Taiwan University_Spotlight130429". ntuweb.cloud.ntu.edu.tw. Retrieved 2021-11-08.
  40. ^ "Avian Model Systems 9". Avian Model Systems 9. Retrieved 2021-11-12.
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