Chemerin peptide
| retinoic acid receptor responder (tazarotene induced) 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | RARRES2 | ||||||
| Alt. symbols | chemerin | ||||||
| NCBI gene | 5919 | ||||||
| HGNC | 9868 | ||||||
| OMIM | 601973 | ||||||
| RefSeq | NM_002889 | ||||||
| UniProt | Q99969 | ||||||
| Other data | |||||||
| Locus | Chr. 7 q36.1 | ||||||
| |||||||
Chemerin peptides are short peptides (on the order of 9 amino acids) that are produced from the carboxyl terminus of the chemokine chemerin. They display the same activities as chemerin, although at higher efficacy and potency.[1]
A particular synthetic chemerin-derived peptide, termed C15, was developed at Oxford University. It showed anti-inflammatory activities. Intraperitoneal administration of C15 (0.32 ng/kg) to mice before zymosan challenge conferred significant protection against zymosan-induced peritonitis, suppressing neutrophil (63%) and monocyte (62%) recruitment with a concomitant reduction in proinflammatory mediator expression.[2]
C15 was found to promote phagocytosis and efferocytosis in peritoneal macrophages at picomolar concentrations. C15 enhanced macrophage clearance of microbial particles and apoptotic cells by factor of 360% in vitro [3]
References
[edit]- ^ Wittamer V, Grégoire F, Robberecht P, Vassart G, Communi D, Parmentier M (March 2004). "The C-terminal nonapeptide of mature chemerin activates the chemerin receptor with low nanomolar potency". J. Biol. Chem. 279 (11): 9956–62. doi:10.1074/jbc.M313016200. PMID 14701797.
- ^ cash, J; Cash JL; Hart R; Russ A; Dixon JP; Colledge WH; Doran J; Hendrick AG; Carlton MB; Greaves DR (Apr 2008). "Synthetic chemerin-derived peptides suppress inflammation through ChemR23". J. Exp. Med. 205 (4): 767–75. doi:10.1084/jem.20071601. PMC 2292217. PMID 18391062.
- ^ Cash, J; Greaves DR (May 2010). "Chemerin peptides promote phagocytosis in a ChemR23 and Syk dependent manner". J. Immunol. 184 (9): 5315–24. doi:10.4049/jimmunol.0903378. PMC 4237835. PMID 20363975.
See also
[edit]
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