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CPN1

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CPN1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCPN1, CPN, SCPN, carboxypeptidase N subunit 1
External IDsOMIM: 603103; MGI: 2135874; HomoloGene: 1002; GeneCards: CPN1; OMA:CPN1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001308

NM_030703

RefSeq (protein)

NP_001299

NP_109628

Location (UCSC)Chr 10: 100.04 – 100.08 MbChr 19: 43.94 – 43.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Carboxypeptidase N catalytic chain is an enzyme that in humans is encoded by the CPN1 gene.[5][6][7]

Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer composed of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency.[7]

In melanocytic cells CPN1 gene expression may be regulated by MITF.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120054Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025196Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Riley DA, Tan F, Miletich DJ, Skidgel RA (Apr 1999). "Chromosomal localization of the genes for human carboxypeptidase D (CPD) and the active 50-kilodalton subunit of human carboxypeptidase N (CPN1)". Genomics. 50 (1): 105–8. doi:10.1006/geno.1998.5295. PMID 9628828.
  6. ^ Gebhard W, Schube M, Eulitz M (Mar 1989). "cDNA cloning and complete primary structure of the small, active subunit of human carboxypeptidase N (kininase 1)". Eur J Biochem. 178 (3): 603–7. doi:10.1111/j.1432-1033.1989.tb14488.x. PMID 2912725.
  7. ^ a b "Entrez Gene: CPN1 carboxypeptidase N, polypeptide 1".
  8. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.
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Further reading

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