34βE12

34βE12, often written as 34betaE12 and also known as CK34βE12 and keratin 903 (CK903), is an antibody specific for high molecular weight cytokeratins 1, 5, 10 and 14.^[1]^[2]

It is sometimes, less precisely, referred to as high-molecular weight keratin (HMWK) and high-molecular weight cytokeratin (HMWCK).

Utility

It is used to stain basal cells in prostatic glands; loss of basal cells is seen in prostate adenocarcinoma (the most common form of prostate cancer).

It can be used to differentiate in situ cancers of the breast; lobular carcinoma in situ (LCIS) exhibits perinuclear staining with 34βE12. Ductal carcinoma in situ (DCIS) does not stain for 34βE12.^[2]

References

^ Aishima S, Asayama Y, Taguchi K, et al. (November 2002). "The utility of keratin 903 as a new prognostic marker in mass-forming-type intrahepatic cholangiocarcinoma". Mod. Pathol. 15 (11): 1181–90. doi:10.1097/01.MP.0000032537.82380.69. PMID 12429797. S2CID 13065115.
^ ^a ^b Yeh IT, Mies C (March 2008). "Application of immunohistochemistry to breast lesions". Arch. Pathol. Lab. Med. 132 (3): 349–358. doi:10.5858/2008-132-349-AOITBL. PMID 18318578.

This article related to pathology is a stub. You can help Wikipedia by expanding it.

[1] Aishima S, Asayama Y, Taguchi K, et al. (November 2002). "The utility of keratin 903 as a new prognostic marker in mass-forming-type intrahepatic cholangiocarcinoma". Mod. Pathol. 15 (11): 1181–90. doi:10.1097/01.MP.0000032537.82380.69. PMID 12429797. S2CID 13065115.

[yeh-2] Yeh IT, Mies C (March 2008). "Application of immunohistochemistry to breast lesions". Arch. Pathol. Lab. Med. 132 (3): 349–358. doi:10.5858/2008-132-349-AOITBL. PMID 18318578.

[1]

[2]

Utility

See also

References