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CHMP5

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CHMP5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCHMP5, C9orf83, HSPC177, PNAS-2, SNF7DC2, Vps60, CGI-34, charged multivesicular body protein 5
External IDsOMIM: 610900; MGI: 1924209; HomoloGene: 5757; GeneCards: CHMP5; OMA:CHMP5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016410
NM_001195536

NM_029814

RefSeq (protein)

NP_001182465
NP_057494

NP_084090

Location (UCSC)n/aChr 4: 40.95 – 40.97 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Charged multivesicular body protein 5 is a protein that in humans is encoded by the CHMP5 gene.[4][5][6]

Function

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CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A, is required for both MVB formation and regulation of cell cycle progression.[6][7]

References

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  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028419Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Ward DM, Vaughn MB, Shiflett SL, White PL, Pollock AL, Hill J, Schnegelberger R, Sundquist WI, Kaplan J (Mar 2005). "The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells". J Biol Chem. 280 (11): 10548–55. doi:10.1074/jbc.M413734200. PMID 15644320.
  5. ^ Howard TL, Stauffer DR, Degnin CR, Hollenberg SM (Sep 2001). "CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins". J Cell Sci. 114 (Pt 13): 2395–404. doi:10.1242/jcs.114.13.2395. PMID 11559748.
  6. ^ a b "Entrez Gene: CHMP5 chromatin modifying protein 5".
  7. ^ Tsang HT, Connell JW, Brown SE, Thompson A, Reid E, Sanderson CM (September 2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.
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Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.