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CGB1

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CGB1
Identifiers
AliasesCGB1, chorionic gonadotropin beta subunit 1, chorionic gonadotropin subunit beta 1
External IDsOMIM: 608823; MGI: 96782; HomoloGene: 137643; GeneCards: CGB1; OMA:CGB1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_033377
NM_001382421

NM_008497

RefSeq (protein)

NP_203695
NP_001369350

NP_032523

Location (UCSC)Chr 19: 49.04 – 49.04 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Choriogonadotropin subunit beta variant 1 is a protein that in humans is encoded by the CGB1 gene.[4][5]

The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranslated region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB1 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (Dirnhofer S, Hermann M, Hittmair A, Hoermann R, Kapelari K, Berger P (December 1996). "Expression of the human chorionic gonadotropin-beta gene cluster in human pituitaries and alternate use of exon 1". J. Clin. Endocrinol. Metab. 81 (12): 4212–7. doi:10.1210/jcem.81.12.8954017. PMID 8954017.). However, a 155 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000267631Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Policastro P, Ovitt CE, Hoshina M, Fukuoka H, Boothby MR, Boime I (Nov 1983). "The beta subunit of human chorionic gonadotropin is encoded by multiple genes". J Biol Chem. 258 (19): 11492–9. doi:10.1016/S0021-9258(17)44254-2. PMID 6194155.
  5. ^ a b "Entrez Gene: CGB1 chorionic gonadotropin, beta polypeptide 1".

Further reading

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