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CBLC

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CBLC
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCBLC, CBL-3, CBL-SL, RNF57, Cbl proto-oncogene C
External IDsOMIM: 608453; MGI: 1931457; HomoloGene: 8108; GeneCards: CBLC; OMA:CBLC - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001130852
NM_012116

NM_001161844
NM_023224

RefSeq (protein)

NP_001124324
NP_036248

NP_001155316
NP_075713

Location (UCSC)Chr 19: 44.78 – 44.8 MbChr 7: 19.51 – 19.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Signal transduction protein CBL-C is a protein that in humans is encoded by the CBLC gene.[5][6][7]

CBL proteins, such as CBLC, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC (MIM 190090) homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling (Keane et al., 1999).[supplied by OMIM][7]

Interactions

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CBLC has been shown to interact with FYN[8] and Epidermal growth factor receptor.[6][9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000142273Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040525Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Keane MM, Ettenberg SA, Nau MM, Banerjee P, Cuello M, Penninger J, Lipkowitz S (Jun 1999). "cbl-3: a new mammalian cbl family protein". Oncogene. 18 (22): 3365–75. doi:10.1038/sj.onc.1202753. PMID 10362357. S2CID 28195948.
  6. ^ a b Kim M, Tezuka T, Suziki Y, Sugano S, Hirai M, Yamamoto T (Dec 1999). "Molecular cloning and characterization of a novel cbl-family gene, cbl-c". Gene. 239 (1): 145–54. doi:10.1016/S0378-1119(99)00356-X. PMID 10571044.
  7. ^ a b "Entrez Gene: CBLC Cas-Br-M (murine) ecotropic retroviral transforming sequence c".
  8. ^ Kim M, Tezuka T, Suziki Y, Sugano S, Hirai M, Yamamoto T (Oct 1999). "Molecular cloning and characterization of a novel cbl-family gene, cbl-c". Gene. 239 (1). NETHERLANDS: 145–54. doi:10.1016/S0378-1119(99)00356-X. ISSN 0378-1119. PMID 10571044.
  9. ^ Keane MM, Ettenberg S A, Nau M M, Banerjee P, Cuello M, Penninger J, Lipkowitz S (Jun 1999). "cbl-3: a new mammalian cbl family protein". Oncogene. 18 (22). ENGLAND: 3365–75. doi:10.1038/sj.onc.1202753. ISSN 0950-9232. PMID 10362357. S2CID 28195948.
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Further reading

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