CTU2

CTU2
Identifiers
Aliases	CTU2, C16orf84, NCS2, UPF0432, cytosolic thiouridylase subunit 2, MFRG
External IDs	OMIM: 617057; MGI: 1914215; HomoloGene: 79815; GeneCards: CTU2; OMA:CTU2 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16q24.3 Start 88,706,483 bp End 88,715,396 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 E1 Start 123,202,882 bp End 123,210,877 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte gonad muscle of thigh gastrocnemius muscle left uterine tube prefrontal cortex apex of heart right frontal lobe Brodmann area 9 cingulate gyrus Top expressed in otic vesicle Paneth cell fossa medullary collecting duct condyle Rostral migratory stream trigeminal ganglion renal corpuscle internal carotid artery hair follicle More reference expression data BioGPS n/a
Gene ontology Molecular function tRNA binding protein binding sulfurtransferase activity nucleotidyltransferase activity Cellular component cytoplasm cytosol protein-containing complex Biological process tRNA wobble uridine modification tRNA thio-modification tRNA processing tRNA wobble position uridine thiolation protein urmylation tRNA modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 348180 66965 Ensembl ENSG00000174177 ENSMUSG00000049482 UniProt Q2VPK5 Q3U308 RefSeq (mRNA) NM_001012759 NM_001012762 NM_001318507 NM_001318513 NM_153775 RefSeq (protein) NP_001012777 NP_001012780 NP_001305436 NP_001305442 NP_722470 Location (UCSC) Chr 16: 88.71 – 88.72 Mb Chr 8: 123.2 – 123.21 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

CTU2 (formerly known as C16orf84) is a human gene located on chromosome 16. The mRNA encodes the longer isoform. The gene encodes a cytoplasmic protein that plays a probable role in tRNA modification.

External links

• Human CTU2 genome location and CTU2 gene details page in the UCSC Genome Browser.

Further reading

• Schlieker CD, Van der Veen AG, Damon JR, Spooner E, Ploegh HL (November 2008). "A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway". Proc. Natl. Acad. Sci. U.S.A. 105 (47): 18255–60. Bibcode:2008PNAS..10518255S. doi:10.1073/pnas.0808756105. PMC 2584574. PMID 19017811.
• Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP (August 2008). "A quantitative atlas of mitotic phosphorylation". Proc. Natl. Acad. Sci. U.S.A. 105 (31): 10762–7. Bibcode:2008PNAS..10510762D. doi:10.1073/pnas.0805139105. PMC 2504835. PMID 18669648.