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Bile-acid 7alpha-dehydratase

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Bile-acid 7α-dehydratase
Identifiers
EC no.4.2.1.106
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins

The enzyme bile-acid 7α-dehydratase (EC 4.2.1.106) catalyzes the chemical reaction

7α,12α-dihydroxy-3-oxochol-4-enoate 12α-hydroxy-3-oxochola-4,6-dienoate + H2O

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 7α,12α-dihydroxy-3-oxochol-4-enoate hydro-lyase (12α-hydroxy-3-oxochola-4,6-dienoate-forming). This enzyme is also called 7α,12α-dihydroxy-3-oxochol-4-enoate hydro-lyase.

References

[edit]
  • Dawson JA, Mallonee DH, Bjorkhem I, Hylemon PB (1996). "Expression and characterization of a C24 bile acid 7 alpha-dehydratase from Eubacterium sp. strain VPI 12708 in Escherichia coli". J. Lipid Res. 37 (6): 1258–67. PMID 8808760.