Benzhydryl compounds
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The benzhydryl compounds are a group of organic compounds whose parent structures include diphenylmethane (which is two benzene rings connected by a single methane), with any number of attached substituents, including bridges. This group typically excludes compounds in which either benzene is fused to another ring (bicyclic, tricyclic, polycyclic)[1] or includes a heteroatom, or where the methane connects to three or four benzenes.
The benzhydryl radical can be abbreviated Ph
2CH• or Bzh.[2]
Carboaromatic
[edit]Alcohols
[edit]- Acyclic: pridinol
- Pyrolidino: diphenylprolinol
- 2-Piperidine: pipradrol
- 4-Piperidine: terfenadine, fexofenadine
- Benzilic ester: QNB, JB-336, JB-318, benactyzine
Alkenes
[edit]- Tricycle: amitriptyline, melitracen, cyclobenzaprine, tianeptine, amineptine, clopenthixol, chlorprothixene, flupentixol, thiothixene, zuclopenthixol
- Tricyclic and piperidine: pimethixene, cyproheptadine
- Acyclic: gilutensin
Alkyl(amine)s
[edit]- Acyclic: (3-phenylpropylamine), tolpropamine, tolterodine
- Piperidine: desoxypipradrol, budipine[3]
- N-alkyl-4-piperidinol: penfluridol
- N-arylalkyl-piperidine: pimozide
- Tetrahydronaphthalene: tametraline (4-phenylaminotetralin), sertraline
- Tetrahydroisoquinoline: nomifensine, diclofensine "tetrahydronaphisoquinoline", dinapsoline (see doxanthrine and dinoxyline)
- Pyrroloisoquinoline: JNJ-7925476
- Indanamine: Lu 19-005
- Tricyclic: 9-Aminomethyl-9,10-dihydroanthracene, phenindamine (see MPTP)
- Tetracyclic: maprotiline, dihydrexidine, butaclamol, ecopipam
- Tetrahydrobenzazepine: SKF-83959, SKF-82958, SKF-81297, SKF 38393, fenoldopam, 6-Br-APB, SCH 23390
- Piperazine: amperozide
- Triazaspiro: fluspirilene
Alkoxy compounds
[edit]- Acyclic (3 °C): diphenhydramine (c.f deramciclane), orphenadrine, p-methyldiphenhydramine
- Acyclic (4 °C): moxastine, Clemastine, embramine,
- Piperazine: GBR-12935, GBR 12909, DBL-583
- Tropine: benztropine, deptropine, etybenzatropine, difluoropine
- Piperidine: diphenylpyraline
- Phthalane: talopram, citalopram
- Octahedral: nefopam
- Benzdihydropyran: A-68930 (isochromene)
Amines
[edit]- Piperazine: cyclizine, clocinizine, hydroxyzine, meclozine, cetirizine, dotarizine, cinnarizine
- Benzazepine: mianserin
- Tetracyclic: dizocilpine
Other
[edit]- Aromatic alkoxy: bifemelane, phenyltoloxamine
- Keto: phenadoxone, methadone, dipipanone, etc.
- Amido: dextromoramide
- Imino: benzodiazepine, GYKI-52895
- Sulfinyl: modafinil, adrafinil
- Pituxate gem-diphenylcyclopropane
Heteroaromatic
[edit]These species are not strictly benzhydryl-containing but are analogous.
Heteroaromatic rings
[edit]- Alkene: thiambutene, loratadine
- Alkylamine: A-86929, amfonelic acid
Benzenes linked by a non-carbon atom
[edit]- Nitrogen: promethazine, imipramine, acepromazine, chlorpromazine, fluphenazine, mesoridazine, levomepromazine, perazine, periciazine, perphenazine, prochlorperazine, sulforidazine, thioridazine, trifluoperazine, triflupromazine, clozapine, thiethylperazine
- Indolic nitrogen: sertindole
- Oxygen: loxapine, asenapine, tyrima
Benzene and heterocycle linked through a non-carbon
[edit]References
[edit]- ^ Benzhydryl Compounds at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ^ "Abbreviations and Symbols". European Journal of Biochemistry. 74 (1): 1–6. 1977. doi:10.1111/j.1432-1033.1977.tb11359.x. ISSN 0014-2956.
- ^ U.S. patent 4,022,786
External links
[edit]- Benzhydryl+Compounds at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Bromodiphenylmethane from PubChem, a.k.a. called benzhydryl bromide
- 1-Benzyl-2-bromobenzene from PubChem, not called benzhydryl bromide