Bromodomain and WD repeat-containing protein 1 (BRWD1) also known as WD repeat-containing protein 9 (WDR9) is a protein that in humans is encoded by the BRWD1gene.[5]
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and 8 WD repeats, and the function of this protein is not known. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates 3 transcript variants diverging at the 3' ends.[5]
Ramos VC, Vidal-Taboada J, Bergoñon S, et al. (2002). "Characterisation and expression analysis of the WDR9 gene, located in the Down critical region-2 of the human chromosome 21". Biochim. Biophys. Acta. 1577 (3): 377–83. doi:10.1016/s0167-4781(02)00421-9. PMID12359327.
Vidal-Taboada JM, Bergoñón S, Sánchez M, et al. (1998). "High resolution physical mapping and identification of transcribed sequences in the Down syndrome region-2". Biochem. Biophys. Res. Commun. 243 (2): 572–8. doi:10.1006/bbrc.1998.8141. PMID9480850.
