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BPTF

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BPTF
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesBPTF, FAC1, FALZ, NURF301, bromodomain PHD finger transcription factor, NEDDFL
External IDsOMIM: 601819; MGI: 2444008; HomoloGene: 114397; GeneCards: BPTF; OMA:BPTF - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004459
NM_182641

NM_001080832
NM_176850
NM_001359590

RefSeq (protein)

NP_004450
NP_872579

n/a

Location (UCSC)Chr 17: 67.83 – 67.98 MbChr 11: 106.92 – 107.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nucleosome-remodeling factor subunit BPTF is a protein that in humans is encoded by the BPTF gene.[5][6][7][8]

This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely.[8]

Interactions

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BPTF has been shown to interact with MAZ.[9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171634Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040481Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bowser R (March 1997). "Assignment of the human FAC1 gene to chromosome 17q24 by fluorescence in situ hybridization". Genomics. 38 (3): 455–7. doi:10.1006/geno.1996.0657. PMID 8975731.
  6. ^ Jones MH, Hamana N, Shimane M (April 2000). "Identification and characterization of BPTF, a novel bromodomain transcription factor". Genomics. 63 (1): 35–9. doi:10.1006/geno.1999.6070. PMID 10662542.
  7. ^ Wysocka J, Swigut T, Xiao H, Milne TA, Kwon SY, Landry J, Kauer M, Tackett AJ, Chait BT, Badenhorst P, Wu C, Allis CD (July 2006). "A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling". Nature. 442 (7098): 86–90. Bibcode:2006Natur.442...86W. doi:10.1038/nature04815. PMID 16728976. S2CID 4389087.
  8. ^ a b "Entrez Gene: BPTF bromodomain PHD finger transcription factor".
  9. ^ Jordan-Sciutto, K L; Dragich J M; Caltagarone J; Hall D J; Bowser R (March 2000). "Fetal Alz-50 clone 1 (FAC1) protein interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity". Biochemistry. 39 (12). UNITED STATES: 3206–15. doi:10.1021/bi992211q. ISSN 0006-2960. PMC 3667205. PMID 10727212.
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Further reading

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