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BCAR3

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BCAR3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBCAR3, NSP2, SH2D3B, breast cancer anti-estrogen resistance 3, AND-34, NSP family adaptor protein, BCAR3 adaptor protein, NSP family member, MIG7
External IDsOMIM: 604704; MGI: 1352501; HomoloGene: 31181; GeneCards: BCAR3; OMA:BCAR3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001261408
NM_001261409
NM_001261410
NM_001308251
NM_003567

NM_013867
NM_001355264

RefSeq (protein)

NP_001248337
NP_001248338
NP_001248339
NP_001295180
NP_003558

NP_038895
NP_001342193

Location (UCSC)Chr 1: 93.56 – 93.85 MbChr 3: 122.09 – 122.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Breast cancer anti-estrogen resistance protein 3 is a protein that in humans is encoded by the BCAR3 gene.[5][6]

Function

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Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hallmark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137936Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028121Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ van Agthoven T, van Agthoven TL, Dekker A, van der Spek PJ, Vreede L, Dorssers LC (Jul 1998). "Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells". EMBO J. 17 (10): 2799–808. doi:10.1093/emboj/17.10.2799. PMC 1170620. PMID 9582273.
  6. ^ a b "Entrez Gene: BCAR3 breast cancer anti-estrogen resistance 3".
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Further reading

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