SEPSECS

SEPSECS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3HL2, 4ZDO, 4ZDL, 4ZDP
Identifiers
Aliases	SEPSECS, LP, PCH2D, SLA, SLA/LP, Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase, soluble liver antigen, SecS
External IDs	OMIM: 613009; MGI: 1098791; HomoloGene: 15031; GeneCards: SEPSECS; OMA:SEPSECS - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	25,160,550 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	52,827,050 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; testicle; ; right lobe of liver; ; jejunal mucosa; ; gonad; ; Achilles tendon; ; body of pancreas; ; pancreatic epithelial cell; ; rectum; ; gastric mucosa;
	Top expressed in
	muscle of thorax; ; islet of Langerhans; ; left lobe of liver; ; thyroid cartilage; ; spermatocyte; ; secondary oocyte; ; right kidney; ; renal pelvis; ; Ileal epithelium; ; zygote;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; tRNA binding; selenotransferase activity; catalytic activity; protein binding; RNA binding; phosphoseryl-selenocysteinyl-tRNA selenium transferase activity;
Cellular component	cytoplasm; cytosol; nucleus;
Biological process	selenocysteine incorporation; protein biosynthesis; selenocysteine metabolic process; selenocysteinyl-tRNA(Sec) biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	51091
	211006
	ENSG00000109618
	ENSMUSG00000029173
	Q9HD40
	Q6P6M7
	NM_001159728; NM_016955
	NM_172490; NM_001363463
	NP_058651
	NP_766078; NP_001350392
	Wikidata
View/Edit Human	View/Edit Mouse

O-phosphoseryl-tRNA(Sec) selenium transferase is an enzyme that in humans is encoded by the SEPSECS gene.^[5]^[6]^[7]^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000109618 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029173 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Xu XM, Mix H, Carlson BA, Grabowski PJ, Gladyshev VN, Berry MJ, Hatfield DL (Dec 2005). "Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery". J. Biol. Chem. 280 (50): 41568–75. doi:10.1074/jbc.M506696200. PMID 16230358.
^ Costa M, Rodríguez-Sánchez JL, Czaja AJ, Gelpí C (Aug 2000). "Isolation and characterization of cDNA encoding the antigenic protein of the human tRNP(Ser)Sec complex recognized by autoantibodies from patients with type-1 autoimmune hepatitis". Clin. Exp. Immunol. 121 (2): 364–74. doi:10.1046/j.1365-2249.2000.01280.x. PMC 1905695. PMID 10931155.
^ Yuan J, Palioura S, Salazar JC, Su D, O'Donoghue P, Hohn MJ, Cardoso AM, Whitman WB, Söll D (Dec 2006). "RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea". Proc. Natl. Acad. Sci. U.S.A. 103 (50): 18923–7. Bibcode:2006PNAS..10318923Y. doi:10.1073/pnas.0609703104. PMC 1748153. PMID 17142313.
^ Xu XM, Carlson BA, Mix H, Zhang Y, Saira K, Glass RS, Berry MJ, Gladyshev VN, Hatfield DL (Apr 2007). "Biosynthesis of selenocysteine on its tRNA in eukaryotes". PLOS Biol. 5 (1): e4. doi:10.1371/journal.pbio.0050004. PMC 1717018. PMID 17194211.
^ "Entrez Gene: SLA/LP soluble liver antigen/liver pancreas antigen".

Herkel J, Heidrich B, Nieraad N, Wies I, Rother M, Lohse AW (2002). "Fine specificity of autoantibodies to soluble liver antigen and liver/pancreas". Hepatology. 35 (2): 403–8. doi:10.1053/jhep.2002.30699. PMID 11826415. S2CID 46400743.
Volkmann M, Martin L, Bäurle A, Heid H, Strassburg CP, Trautwein C, Fiehn W, Manns MP (2001). "Soluble liver antigen: isolation of a 35-kd recombinant protein (SLA-p35) specifically recognizing sera from patients with autoimmune hepatitis". Hepatology. 33 (3): 591–6. doi:10.1053/jhep.2001.22218. PMID 11230739. S2CID 11978013.
Wies I, Brunner S, Henninger J, Herkel J, Kanzler S, Meyer zum Büschenfelde KH, Lohse AW (2000). "Identification of target antigen for SLA/LP autoantibodies in autoimmune hepatitis". Lancet. 355 (9214): 1510–5. doi:10.1016/S0140-6736(00)02166-8. PMID 10801173. S2CID 45159673.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000109618 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029173 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16230358-5] Xu XM, Mix H, Carlson BA, Grabowski PJ, Gladyshev VN, Berry MJ, Hatfield DL (Dec 2005). "Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery". J. Biol. Chem. 280 (50): 41568–75. doi:10.1074/jbc.M506696200. PMID 16230358.

[pmid10931155-6] Costa M, Rodríguez-Sánchez JL, Czaja AJ, Gelpí C (Aug 2000). "Isolation and characterization of cDNA encoding the antigenic protein of the human tRNP(Ser)Sec complex recognized by autoantibodies from patients with type-1 autoimmune hepatitis". Clin. Exp. Immunol. 121 (2): 364–74. doi:10.1046/j.1365-2249.2000.01280.x. PMC 1905695. PMID 10931155.

[pmid17142313-7] Yuan J, Palioura S, Salazar JC, Su D, O'Donoghue P, Hohn MJ, Cardoso AM, Whitman WB, Söll D (Dec 2006). "RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea". Proc. Natl. Acad. Sci. U.S.A. 103 (50): 18923–7. Bibcode:2006PNAS..10318923Y. doi:10.1073/pnas.0609703104. PMC 1748153. PMID 17142313.

[pmid17194211-8] Xu XM, Carlson BA, Mix H, Zhang Y, Saira K, Glass RS, Berry MJ, Gladyshev VN, Hatfield DL (Apr 2007). "Biosynthesis of selenocysteine on its tRNA in eukaryotes". PLOS Biol. 5 (1): e4. doi:10.1371/journal.pbio.0050004. PMC 1717018. PMID 17194211.

[entrez-9] "Entrez Gene: SLA/LP soluble liver antigen/liver pancreas antigen".

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References

Further reading