Myotonia
 | This article needs more reliable medical references for verification or relies too heavily on primary sources. (November 2020) |  |
| Myotonia | |
|---|---|
| Specialty | Neurology, neuromuscular medicine, medical genetics  |
Myotonia is a symptom of a small handful of certain neuromuscular disorders characterized by delayed relaxation (prolonged contraction) of the skeletal muscles after voluntary contraction or electrical stimulation, and the muscle shows an abnormal EMG.[1][2]
Myotonia is the defining symptom of many channelopathies (diseases of ion channel transport) such as myotonia congenita, paramyotonia congenita and myotonic dystrophy.[3][4]
Brody disease (a disease of ion pump transport) has symptoms similar to myotonia congenita, however, the delayed muscle relaxation is pseudo-myotonia as the EMG is normal.[5] Other diseases that exhibit pseudo-myotonia are myositis, glycogen storage diseases, hyperkalemic periodic paralysis, root disease, anterior horn cell disorders, Isaacs syndrome, and Hoffmann syndrome.[2][6][7]
Generally, repeated contraction of the muscle can alleviate the myotonia and relax the muscles thus improving the condition, however, this is not the case in paramyotonia congenita. This phenomenon is known as the "warm-up" reflex[8] and is not to be confused with warming up before exercise, though they may appear similar. Individuals with the disorder may have trouble releasing their grip on objects or may have difficulty rising from a sitting position and a stiff, awkward gait.
Myotonia can affect all muscle groups; however, the pattern of affected muscles can vary depending on the specific disorder involved.
People with disorders involving myotonia can have life-threatening reactions to certain anaesthetics called anaesthesia-induced rhabdomyolysis.
Causes
[edit]Myotonia may present in the following diseases, with different causes related to the ion channels in the skeletal muscle fiber membrane (sarcolemma).[9]
Myotonic dystrophy
[edit]Two documented types, DM1 and DM2 exist. In myotonic dystrophy a nucleotide expansion of either of two genes, related to type of disease, results in failure of correct expression (splicing of the mRNA) of the ClC-1 ion channel, due to accumulation of RNA in the cytosol of the cell.[10][11] The ClC-1 ion channel is responsible for the major part of chloride conductance in the skeletal muscle cell,[12] and lack of sufficient chloride conductance may result in myotonia, (see myotonia congenita). When the splicing of the mRNA was corrected in vitro, ClC-1 channel function was greatly improved and myotonia was abolished.[13]
Myotonia congenita
[edit](Congenital myotonia) of which two types called Becker's disease and Thomsen's disease exist.[14] Both diseases are caused by mutations in the gene CLCN1 encoding the ClC-1 ion channel. More than 130 different mutations exist in total, and a large phenotypic variation is therefore present in this disease.[15] The mutations are loss-of-function mutations that render the ClC-1 ion channel dysfunctional to varying degrees, with reduced chloride conductance as a result. Reduced chloride conductance may result in myotonia, due to accumulation of potassium in the transverse-tubules in skeletal muscle (see myotonia congenita). This is the same genetic disease that makes certain strains of North American goats faint when scared.[16]
Symptoms of myotonia (documented in myotonia congenita) are more frequently experienced in women during pregnancy.[17]
Myotonia could be caused by genetic mutations in the SCN4A gene that encodes the skeletal muscle sodium channel subtype 4 (Nav1.4). Some studies have suggested that changes in physiological pH could have modulatory effects on Nav1.4 sodium channels, which could have manifestations in myotonic phenotypes.[18]
Paramyotonia congenita
[edit]This disease results from mutation in the SCN4A gene encoding the voltage-gated sodium channel Nav1.4 in skeletal muscle fiber membrane. Mutations may alter the kinetics of the channel, such that the channel fails to inactivate properly, thus allowing spontaneous action potentials to occur after voluntary activity has terminated, prolonging relaxation of the muscle, or can result in paralysis if the relaxation is severely prolonged (see SCN4A). This inability of muscles to relax worsening with exercise is often termed "paradoxical myotonia." Paramyotonia also frequently triggered by exercise, cold, and potassium.[19]
Potassium-aggravated myotonia
[edit]Potassium-aggravated myotonia (PAM) results from in a mututation of the SCN4A gene that causes skeletal muscles to be unable to relax after contracting in bouts, typically following the consumption of potassium rich food.[20] It is debated if potassium-aggravated myotonia is a distinct disease from Paramyotonia Congenita, and recent academic papers have classified it both ways.[21][22]
Hyperkalemic periodic paralysis
[edit]Also known as HyperKPP. Similar to Paramyotonia Congenita, where potassium exacerbates myotonia in many phenotypes, Hyperkalemic Periodic Paralysis is another disorder of the SCN4A gene where high blood potassium levels result in muscle weakness, muscle paralysis (through weakness or through over excitation preventing movement), and sometimes myotonia. Many phenotypes of HyperKPP result in issues regulating blood potassium levels, often cause it to be high or causing hyperkalemia, further exacerbating the condition.[9]
Hypokalemic periodic paralysis
[edit]Also known as HypoKPP. Similar to HyperKPP above, except that it's triggered by (and often causes) low potassium levels and hypokalemia. It too can result in myotonia, in addition to weakness and paralysis (from both lack of and excess signal to muscles). It also has been found to occur due to gene mutations in the calcium channel gene CACNA1S and, less frequently, in the SCN4A gene.[9]
Neuromyotonia
[edit]Neuromyotonia (also known as Isaac's Syndrome or NMT) causes peripheral nerve hyperexcitability that causes spontaneous muscular activity resulting from repetitive motor unit action potentials of peripheral origin. 100-200 cases have been reported.[23]
Other
[edit]Myotonia occurs also in certain types of limb-girdle muscular dystrophies, myofibrillary myopathies, distal myopathies, and inclusion body myopathies.[24] Other channelopathies may cause it as well.[3] It is also associated with Schwartz–Jampel syndrome.[25]
See also
[edit]References
[edit]- ^ Gutmann, Laurie; Phillips, Lawrence H., 2nd (September 1991). "Myotonia congenita". Seminars in Neurology. 11 (3): 244–8. doi:10.1055/s-2008-1041228. PMID 1947487. S2CID 20602810.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: numeric names: authors list (link) - ^ a b Killian, James M. (1 January 2010), Rolak, Loren A. (ed.), "CHAPTER 26 - Electromyography", Neurology Secrets (Fifth Edition), Philadelphia: Mosby, pp. 428–435, ISBN 978-0-323-05712-7, retrieved 28 May 2023
- ^ a b "Myotonia Information Page | National Institute of Neurological Disorders and Stroke". www.ninds.nih.gov. Retrieved 1 October 2019.
- ^ Kim, June-Bum (January 2014). "Channelopathies". Korean Journal of Pediatrics. 57 (1): 1–18. doi:10.3345/kjp.2014.57.1.1. ISSN 1738-1061. PMC 3935107. PMID 24578711.
- ^ Braz, Luís; Soares-Dos-Reis, Ricardo; Seabra, Mafalda; Silveira, Fernando; Guimarães, Joana (October 2019). "Brody disease: when myotonia is not myotonia". Practical Neurology. 19 (5): 417–419. doi:10.1136/practneurol-2019-002224. ISSN 1474-7766. PMID 30996034. S2CID 122401141.
- ^ "Isaacs Syndrome - Neurologic Disorders". Merck Manuals Professional Edition. Retrieved 28 May 2023.
- ^ Tyler, Frank H. (1966), Kuhn, Erich (ed.), "The Differentiation of Myotonia and Pseudomyotonia", Progressive Muskeldystrophie Myotonie · Myasthenie: Symposium vom 30. November bis 4. Dezember 1965 anläßlich der 125. Wiederkehr des Geburtstages von Wilhelm Erb (in German), Berlin, Heidelberg: Springer, pp. 289–294, doi:10.1007/978-3-642-92920-5_39, ISBN 978-3-642-92920-5, retrieved 28 May 2023
- ^ Birnberger, KL; Rüdel, R; Struppler, A (1 September 1975). "Clinical and electrophysiological observations in patients with myotonic muscle disease and the therapeutic effect of N-propyl-ajmaline". Journal of Neurology. 210 (2): 99–110. doi:10.1007/BF00316381. PMID 51920. S2CID 10804605.
- ^ a b c Trivedi, Jaya R. (December 2022). "Muscle Channelopathies". CONTINUUM: Lifelong Learning in Neurology. 28 (6): 1778–1799. doi:10.1212/CON.0000000000001183. ISSN 1538-6899. PMID 36537980.
- ^ Mankodi, A; Takahashi, MP; Jiang, H; Beck, CL; Bowers, WJ; Moxley, RT; Cannon, SC; Thornton, CA (July 2002). "Expanded CUG repeats trigger aberrant splicing of ClC-1 chloride channel pre-mRNA and hyperexcitability of skeletal muscle in myotonic dystrophy". Molecular Cell. 10 (1): 35–44. doi:10.1016/s1097-2765(02)00563-4. PMID 12150905.
- ^ Charlet-B, N; Savkur, RS; Singh, G; Philips, AV; Grice, EA; Cooper, TA (July 2002). "Loss of the muscle-specific chloride channel in type 1 myotonic dystrophy due to misregulated alternative splicing". Molecular Cell. 10 (1): 45–53. doi:10.1016/s1097-2765(02)00572-5. PMID 12150906.
- ^ Kwieciński, H; Lehmann-Horn, F; Rüdel, R (January 1984). "The resting membrane parameters of human intercostal muscle at low, normal, and high extracellular potassium". Muscle & Nerve. 7 (1): 60–5. doi:10.1002/mus.880070110. PMID 6700631. S2CID 17368122.
- ^ Wheeler, TM; Lueck, JD; Swanson, MS; Dirksen, RT; Thornton, CA (December 2007). "Correction of ClC-1 splicing eliminates chloride channelopathy and myotonia in mouse models of myotonic dystrophy". The Journal of Clinical Investigation. 117 (12): 3952–7. doi:10.1172/JCI33355. PMC 2075481. PMID 18008009.
- ^ Lossin, Christoph; George AL jr (2008). Chapter 2 Myotonia Congenita. Advances in Genetics. Vol. 63. pp. 25–55. doi:10.1016/S0065-2660(08)01002-X. ISBN 978-0-12-374527-9. PMID 19185184.
- ^ Colding-Jørgensen, Eskild (July 2005). "Phenotypic variability in myotonia congenita". Muscle & Nerve. 32 (1): 19–34. doi:10.1002/mus.20295. PMID 15786415. S2CID 8336138.
- ^ Beck, C L; Fahlke, C; George, A L (October 1996). "Molecular basis for decreased muscle chloride conductance in the myotonic goat". Proceedings of the National Academy of Sciences. 93 (20): 11248–11252. Bibcode:1996PNAS...9311248B. doi:10.1073/pnas.93.20.11248. ISSN 0027-8424. PMC 38315. PMID 8855341.
- ^ Basu, A; Nishanth, P; Ifaturoti, O (July 2009). "Pregnancy in women with myotonia congenita". International Journal of Gynaecology and Obstetrics. 106 (1): 62–3. doi:10.1016/j.ijgo.2009.01.031. PMID 19368920. S2CID 22924091.
- ^ Ghovanloo MR, Abdelsayed M, Peters CH, Ruben PC (2018). "A Mixed Periodic Paralysis & Myotonia Mutant, P1158S, Imparts pH-Sensitivity in Skeletal Muscle Voltage-gated Sodium Channels". Scientific Reports. 8 (1): 13. Bibcode:2018NatSR...8.6304G. doi:10.1038/s41598-018-24719-y. PMC 5908869. PMID 29674667.
- ^ Vicart, S.; Sternberg, D.; Fontaine, B.; Meola, G. (1 October 2005). "Human skeletal muscle sodium channelopathies". Neurological Sciences. 26 (4): 194–202. doi:10.1007/s10072-005-0461-x. ISSN 1590-3478. PMID 16193245. S2CID 27141272.
- ^ Reference, Genetics Home. "Potassium-aggravated myotonia". Genetics Home Reference. Retrieved 17 November 2019.
- ^ McClatchey, Andrea I.; McKenna-Yasek, Diane; Cros, Didier; Worthen, Hilary G.; Kuncl, Ralph W.; DeSilva, Shari M.; Cornblath, David R.; Gusella, James F.; Brown, Robert H. (October 1992). "Novel mutations in families with unusual and variable disorders of the skeletal muscle sodium channel". Nature Genetics. 2 (2): 148–152. doi:10.1038/ng1092-148. ISSN 1061-4036. PMID 1338909. S2CID 12492661.
- ^ Vicart, S.; Sternberg, D.; Fontaine, B.; Meola, G. (October 2005). "Human skeletal muscle sodium channelopathies". Neurological Sciences. 26 (4): 194–202. doi:10.1007/s10072-005-0461-x. ISSN 1590-1874. PMID 16193245. S2CID 27141272.
- ^ RESERVED, INSERM US14-- ALL RIGHTS. "Orphanet: Search a disease". www.orpha.net. Retrieved 17 November 2019.
{{cite web}}: CS1 maint: numeric names: authors list (link) - ^ Narayanaswami, P; Weiss, M (October 2014). "Evidence-based guideline summary: diagnosis and treatment of limb-girdle and distal dystrophies: report of the guideline development subcommittee of the American Academy of Neurology and the practice issues review panel of the American Association of Neuromuscular & Electrodiagnostic Medicine". Neurology. 83 (16): 1453–1463. doi:10.1212/WNL.0000000000000892. PMC 4206155. PMID 25313375.
- ^ "Schwartz Jampel syndrome | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program". rarediseases.info.nih.gov. Retrieved 17 November 2019.