Tilorone

Tilorone
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	By mouth (tablets)
ATC code	J05AX19 (WHO) ;
Pharmacokinetic data
Bioavailability	60%
Protein binding	~80%
Metabolism	Nil
Elimination half-life	48 hours
Excretion	Feces (70%), urine (9%)
Identifiers
	IUPAC name 2,7-Bis(2-diethylaminoethoxy)fluoren-9-one;
CAS Number	27591-97-5 ;
PubChem CID	5475;
ChemSpider	5276 ;
UNII	O6W7VEW6KS;
KEGG	D06149 ;
ChEBI	CHEBI:147347;
ChEMBL	ChEMBL47298 ;
CompTox Dashboard (EPA)	DTXSID1045958 ;
Chemical and physical data
Formula	C25H34N2O3
Molar mass	410.558 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCN(CC)CCOc1ccc-2c(c1)C(=O)c3c2ccc(c3)OCCN(CC)CC;
	InChI InChI=1S/C25H34N2O3/c1-5-26(6-2)13-15-29-19-9-11-21-22-12-10-20(30-16-14-27(7-3)8-4)18-24(22)25(28)23(21)17-19/h9-12,17-18H,5-8,13-16H2,1-4H3 ; Key:MPMFCABZENCRHV-UHFFFAOYSA-N ;
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Tilorone (trade names Amixin, Lavomax and others) is the first recognized synthetic, small molecular weight compound that is an orally active interferon inducer.^[2] It is used as an antiviral drug in some countries which do not require double-blind placebo-controlled studies, including Russia. It is effective against Ebola virus in mice.^[3] It shows activity against Eastern equine encephalitis and related viruses.^[4]

Pharmacology

Tilorone activates the production of interferon.^[2]

References

^ "Registry of Medicinal Products (RLS). Tilorone: Prescribing Information" (in Russian). Retrieved 2 October 2016.
^ ^a ^b Stringfellow DA, Glasgow LA (August 1972). "Tilorone hydrochloride: an oral interferon-inducing agent". Antimicrobial Agents and Chemotherapy. 2 (2): 73–78. doi:10.1128/aac.2.2.73. PMC 444270. PMID 4670490.
^ Ekins S, Lingerfelt MA, Comer JE, Freiberg AN, Mirsalis JC, O'Loughlin K, et al. (February 2018). "Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection". Antimicrobial Agents and Chemotherapy. 62 (2). doi:10.1128/AAC.01711-17. PMC 5786809. PMID 29133569.
^ Ogorek TJ, Golden JE. Advances in the Development of Small Molecule Antivirals against Equine Encephalitic Viruses. Viruses. 2023 Feb 1;15(2):413. doi:10.3390/v15020413 PMID 36851628

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[1] "Registry of Medicinal Products (RLS). Tilorone: Prescribing Information" (in Russian). Retrieved 2 October 2016.

[stringfellow-2] Stringfellow DA, Glasgow LA (August 1972). "Tilorone hydrochloride: an oral interferon-inducing agent". Antimicrobial Agents and Chemotherapy. 2 (2): 73–78. doi:10.1128/aac.2.2.73. PMC 444270. PMID 4670490.

[3] Ekins S, Lingerfelt MA, Comer JE, Freiberg AN, Mirsalis JC, O'Loughlin K, et al. (February 2018). "Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection". Antimicrobial Agents and Chemotherapy. 62 (2). doi:10.1128/AAC.01711-17. PMC 5786809. PMID 29133569.

[4] Ogorek TJ, Golden JE. Advances in the Development of Small Molecule Antivirals against Equine Encephalitic Viruses. Viruses. 2023 Feb 1;15(2):413. doi:10.3390/v15020413 PMID 36851628

[1]

[2]

[3]

[4]

Pharmacology

See also

References