Kopexil
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| IUPAC names
2,3-Dihydro-3-hydroxy-2-imino-4-pyrimidinamine
2,4-Diaminopyrimidine 3-N-oxide | |
| Other names
Aminexil
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| Identifiers | |
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3D model (JSmol)
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| ChemSpider | |
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PubChem CID
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CompTox Dashboard (EPA)
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| Properties | |
| C4H6N4O | |
| Molar mass | 126.119 g·mol−1 |
| Appearance | white odorless crystals[1] |
| Melting point | 210 to 218 °C (410 to 424 °F; 483 to 491 K)[1] |
| slightly soluble[1] | |
| Hazards | |
| GHS labelling: | |
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| Warning | |
| H302 | |
| P264, P270, P301+P312, P330, P501 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Kopexil (INCI name diaminopyrimidine oxide, trade name Aminexil) is a chemical compound similar to minoxidil. Minoxidil was originally used to treat high blood pressure; a side effect was increased body hair. Both compounds have been used for therapy of alopecia.[2] Kopexil is not approved for use as a drug in the United States or in Europe.
Chemical structure
[edit]Kopexil is an N-oxide, a group of substances in which the nitrogen atom of a tertiary amine is oxidized. The compound can exist in two tautomeric forms.
Mechanism of action
[edit]The exact mechanism of action of kopexil is unknown. There is no proof of therapeutic effect for kopexil against alopecia.[3]
References
[edit]- ^ a b c MSDS for Kopexil at Kumar Organics. Archived 2015-07-22 at the Wayback Machine March 28th 2012.
- ^ Trüeb RM, de Viragh PA: Status of scalp hair and therapy of alopecia in men in Switzerland; PMID 11256223.
- ^ Wolfgang Raab: Haarerkrankungen in der dermatologischen Praxis, p. 82, at Google Books (German).
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