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Pantetheine-phosphate adenylyltransferase

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pantetheine-phosphate adenylyltransferase
Phosphopantetheine adenylyltransferase from Thermotoga maritima. 4'-Phosphopantetheine shown as spheres. PDB 1vlh
Identifiers
EC no.2.7.7.3
CAS no.9026-99-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a pantetheine-phosphate adenylyltransferase (EC 2.7.7.3) is an enzyme that catalyzes the chemical reaction

ATP + 4'-Phosphopantetheine diphosphate + 3'-dephospho-CoA

Thus, the two substrates of this enzyme are ATP and 4'-Phosphopantetheine, whereas its two products are diphosphate and 3'-dephospho-CoA.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ATP:pantetheine-4'-phosphate adenylyltransferase. Other names in common use include dephospho-CoA pyrophosphorylase, pantetheine phosphate adenylyltransferase, dephospho-coenzyme A pyrophosphorylase, and 3'-dephospho-CoA pyrophosphorylase. This enzyme participates in pantothenate and coa biosynthesis.

Structural studies

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As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1B6T, 1GN8, 1H1T, 1O6B, 1OD6, 1QJC, 1TFU, and 1VLH.

References

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