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(deoxy)nucleoside-phosphate kinase

From Wikipedia, the free encyclopedia
(deoxy)nucleoside-phosphate kinase
Identifiers
EC no.2.7.4.13
CAS no.37278-20-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins

In enzymology, a (deoxy)nucleoside-phosphate kinase (EC 2.7.4.13) is an enzyme that catalyzes the chemical reaction

ATP + deoxynucleoside phosphate ADP + deoxynucleoside diphosphate

Thus, the two substrates of this enzyme are ATP and deoxynucleoside phosphate, whereas its two products are ADP and deoxynucleoside diphosphate.[1]

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:deoxynucleoside-phosphate phosphotransferase. Other names in common use include deoxynucleoside monophosphate kinase, deoxyribonucleoside monophosphokinase, and deoxynucleoside-5'-monophosphate kinase.

Structural studies

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As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1DEK and 1DEL.

References

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  1. ^ BESSMAN MJ, HERRIOTT ST, ORR MJ (1965). "The Enzymology of Virus-Infected Bacteria. Vi. Purification and Properties of the Deoxynucleotide Kinase Induced by Bacteriophage T5". J. Biol. Chem. 240: 439–45. doi:10.1016/S0021-9258(18)97668-4. PMID 14253449.